Specificity Protein 1 Antibody / SP1

• Catalog number
  R31910
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Specificity Protein 1 / SP1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.1-0.5ug/ml
• Notes
  Optimal dilution of the SP1 antibody should be determined by the researcher.
• Intented use
  This SP1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P08047
• Purity
  Antigen affinity
• Description
  SP1 (transcription factor Sp1), also known as Specificity Protein 1, is a human transcription factor involved in gene expression in the early development of an organism. It belongs to the Sp/KLF family of transcription factors. The protein is 785 amino acids long, with a molecular weight of 81 kDA. By fluorescence in situ hybridization, Matera and Ward (1993) mapped the SP1 gene to 12q13. By in situ hybridization, Gaynor et al. (1993) concluded that 12q13.1 is the most probable location of the SP1 gene. Segmentation in Drosophila is based on a cascade of hierarchical gene interactions initiated by maternally deposited morphogens that define the spatially restricted domains of gap gene expression at blastoderm. The formation of 7 head segments depends on the function of several genes. Wimmer et al. (1993) showed that one of these genes is the Drosophila homolog of the human transcription factor SP1.
• Immunogen
  Amino acids EAICPEGIARLANSGINVMQVADLQSINISGNGF of human SP1 were used as the immunogen for the SP1 antibody.
• Storage
  After reconstitution, the SP1 antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Protein   SP1  
• Gene symbol
  SP1, PRSS55, ST14
• Short name
  Anti-Specificity Protein 1 / SP1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to Specificity Protein 1 / SP1
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:11205
• Gene
  SP1
• Long gene name
  Sp1 transcription factor
• Synonyms name
  • specificity protein 1
• GenBank acession
  • J03133
• Locus
  12q13.13
• Discovery year
  1991-06-04
• Entrez gene record
  6667
• Pubmed identfication
  • 1662663
• Classification
  • Sp transcription factors
  • Zinc fingers C2H2-type
• VEGA ID
  OTTHUMG00000170047

Gene info

• Identity
  HGNC:30824
• Gene
  PRSS55
• Long gene name
  serine protease 55
• Synonyms gene name
  • protease, serine 55
• Synonyms
  • T-SP1
  • UNQ9391
  • CT153
• GenBank acession
  • AY358867
• Locus
  8p23.1
• Discovery year
  2010-04-14
• Entrez gene record
  203074
• Pubmed identfication
  • 12975309
  • 18844450
• RefSeq identity
  • NM_198464
• Classification
  • Serine proteases
• VEGA ID
  OTTHUMG00000129345

Gene info

• Identity
  HGNC:11344
• Gene
  ST14
• Long gene name
  ST14 transmembrane serine protease matriptase
• Synonyms gene
  • PRSS14
• Synonyms gene name
  • suppression of tumorigenicity 14 (colon carcinoma)
  • suppression of tumorigenicity 14
• Synonyms
  • SNC19
  • HAI
  • MT-SP1
  • TMPRSS14
  • CAP3
• Synonyms name
  • epithin
  • matriptase
  • channel–activating protein 3
• GenBank acession
  • AF118224
• Locus
  11q24.3
• Discovery year
  1998-05-05
• Entrez gene record
  6768
• Pubmed identfication
  • 9925927
  • 10373424
• Classification
  • Type II transmembrane serine proteases
• VEGA ID
  OTTHUMG00000165768

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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