SNAP23 Antibody

• Catalog number
  R30867
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  SNAP23
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P, IHC-F, ICC
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml,IHC (Frozen): 0.5-1ug/ml,Immunocytochemistry: 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the SNAP23 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This SNAP23 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  O00161
• Purity
  Antigen affinity
• Description
  Synaptosomal-Associated Protein, 23-KD is a protein that in humans is encoded by the SNAP23 gene. The gene has 8 exons, with the initiation codon located in exon 2 and is mapped on 15q15.1-q15.2. Its amino acid sequence is 59% identical to that of SNAP25. Northern blot analysis revealed that SNAP23 is ubiquitously expressed. The protein is able to bind to multiple syntaxins as well as to multiple vesicle-associated membrane proteins. After relocation, it is required for exocytosis, implying a crucial role in promoting membrane fusion. TIVAMP-containing vesicles were concentrated in the apical domain of epithelial cells. STX3A and SNAP23 were codistributed at the apical plasma membrane, where they formed N-ethyl maleimide-dependent SNARE complexes with TIVAMP and cellubrevin. It is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion.
• Immunogen
  An amino acid sequence from the C-terminus of human SNAP23 (DTNRDRIDIANARAKKLIDS) was used as the immunogen for this SNAP23 antibody.
• Storage
  After reconstitution, the SNAP23 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SNAP23  
• Gene symbol
  SNAP23
• Short name
  Anti-SNAP23
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to SNAP23
• Alternative technique
  antibodies
• Alternative to gene target
  synaptosomal-associated protein, 23kDa, HsT17016 and SNAP-23 and SNAP23A and SNAP23B, SNAP23 and IDBG-7946 and ENSG00000092531 and 8773, protein binding, nuclei, Snap23 and IDBG-201120 and ENSMUSG00000027287 and 20619, SNAP23 and IDBG-646359 and ENSBTAG00000005661 and 100336178,522423

Gene info

• Identity
  HGNC:11131
• Gene
  SNAP23
• Long gene name
  synaptosome associated protein 23
• Synonyms gene name
  • synaptosomal-associated protein, 23kDa
• Synonyms
  • SNAP23A
  • SNAP23B
  • HsT17016
• GenBank acession
  • Y09567
• Locus
  15q15.1-q15.2
• Discovery year
  1998-12-17
• Entrez gene record
  8773
• Pubmed identfication
  • 9070898
  • 8663154
• RefSeq identity
  • NM_003825
• Classification
  • SNAREs
• VEGA ID
  OTTHUMG00000130625

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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