SLUG Antibody

• Catalog number
  F47912-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  SLUG
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the SLUG antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This SLUG antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  O43623
• Purity
  Purified
• Description
  SNAI2/SLUG is a transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis. [UniProt]
• Immunogen
  A portion of amino acids 1-30 from the human protein was used as the immunogen for this SLUG antibody.
• Storage
  Aliquot the SLUG antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SLUG  
• Gene symbol
  SNAI2
• Short name
  Anti-SLUG
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to SLUG
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:11094
• Gene
  SNAI2
• Long gene name
  snail family transcriptional repressor 2
• Synonyms gene
  • SLUG
• Synonyms gene name
  • slug homolog, zinc finger protein (chicken)
  • snail homolog 2 (Drosophila)
  • snail family zinc finger 2
• Synonyms
  • SLUGH1
  • SNAIL2
  • SLUGH
• GenBank acession
  • U97060
• Locus
  8q11.21
• Discovery year
  1998-07-03
• Entrez gene record
  6591
• Pubmed identfication
  • 9337409
  • 9721220
• RefSeq identity
  • NM_003068
• Classification
  • Zinc fingers C2H2-type
  • SNAG transcriptional repressors
• VEGA ID
  OTTHUMG00000149912
• Locus Specific Databases
  • LRG_1359

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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