ROS1 Antibody

• Catalog number
  F52830-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  ROS1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the ROS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This ROS1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P08922
• Purity
  Antigen affinity
• Description
  Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
• Immunogen
  This ROS1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 1744-1777 amino acids from the C-terminal region of human ROS1.
• Storage
  Aliquot the ROS1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ROS1  
• Gene symbol
  ROS1
• Short name
  Anti-ROS1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to ROS1
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:10261
• Gene
  ROS1
• Long gene name
  ROS proto-oncogene 1, receptor tyrosine kinase
• Synonyms gene name
  • v-ros avian UR2 sarcoma virus oncogene homolog 1
  • v-ros UR2 sarcoma virus oncogene homolog 1 (avian)
  • c-ros oncogene 1 , receptor tyrosine kinase
• Synonyms
  • MCF3
  • ROS
  • c-ros-1
• GenBank acession
  • M13599
• Locus
  6q22.1
• Discovery year
  1986-01-01
• Entrez gene record
  6098
• Pubmed identfication
  • 1611909
• Classification
  • Receptor tyrosine kinases
  • Fibronectin type III domain containing
• VEGA ID
  OTTHUMG00000016188
• Locus Specific Databases
  • LRG_997

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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