RAB7A Antibody

• Catalog number
  R32124
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  RAB7A
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.1-0.5ug/ml
• Notes
  Optimal dilution of the RAB7 antibody should be determined by the researcher.
• Intented use
  This RAB7 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P51149
• Purity
  Antigen affinity
• Description
  Ras-related protein Rab-7a is a protein that in humans is encoded by the RAB7A gene. RAB7A functions as a key regulator in endo-lysosomal trafficking, governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positions, and endosome-lysosome transport through different protein-protein interaction cascades. Furthermore, RAB7A is involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes through modulation of SOX10 and the oncogene MYC. Mutations in the lysosomal pathway result in tumor progression in melanoma cells.
• Immunogen
  Amino acids KEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDKND of human RAB7A were used as the immunogen for the RAB7 antibody.
• Storage
  After reconstitution, the RAB7 antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Localization
  Cytoplasmic
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  RAB7A  
• Gene symbol
  RAB7A
• Short name
  Anti-RAB7A
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to RAB7A
• Alternative technique
  antibodies
• Alternative to gene target
  RAB7A, member RAS oncogene family, PRO2706 and RAB7, RAB7A and IDBG-55277 and ENSG00000075785 and 7879, Rac GTPase binding, nuclei, Rab7 and IDBG-253533 and ENSMUSG00000079477 and 19349, BT.41314 and IDBG-646498 and ENSBTAG00000010193 and 509970

Gene info

• Identity
  HGNC:9788
• Gene
  RAB7A
• Long gene name
  RAB7A, member RAS oncogene family
• Synonyms gene
  • RAB7
  • CMT2B
• Synonyms gene name
  • RAB7, member RAS oncogene family
  • Charcot-Marie-Tooth neuropathy 2B
• GenBank acession
  • X93499
• Locus
  3q21.3
• Discovery year
  1999-03-24
• Entrez gene record
  7879
• Pubmed identfication
  • 9126495
  • 9428630
  • 12545426
• Classification
  • RAB, member RAS oncogene GTPases
• VEGA ID
  OTTHUMG00000159812
• Locus Specific Databases
  • LRG_266

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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