PTEN Antibody
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Catalog numberV2805-100UG
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PricePlease ask
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Size0.1mg
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CategoryAntibody
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Concentration0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
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FormPurified
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ConjugationUnconjugated
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ClonePolyclonal antibody
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Recognised antigenPTEN
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Host animalRabbit (Oryctolagus cuniculus)
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ClonalityPolyclonal (rabbit origin)
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Species reactivityHuman (Homo sapiens). Other species not tested. ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
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Tested applicationsFACS, IF, WB
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Recommended dilutionsFlow Cytometry: 0.5-1ug/million cells,Immunofluorescence: 1-2ug/ml,Western blot: 0.5-1ug/ml
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NotesOptimal dilution of the PTEN antibody should be determined by the researcher.
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Intented useThis PTEN antibodyis to be used only for research purposes and not for diagnostics..
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UniprotP60484
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PurityPurified by protein A Affinity Chromatography
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DescriptionRecognizes a protein of 55kDa, which is identified as PTEN. PTEN is one of the most commonly lost tumor suppressors in human cancer; in fact, up to 70% of men with prostate cancer are estimated to have lost a copy of the PTEN gene at the time of diagnosis. During tumor development, mutations and deletions of PTEN occur that inactivate its enzymatic activity leading to increased cell proliferation and reduced cell death. Frequent genetic inactivation of PTEN occurs in glioblastoma, endometrial cancer, and prostate cancer; and reduced expression is found in many other tumor types such as lung and breast cancer. In breast and prostate cancer, loss of PTEN expression has been shown to correlate positively with advanced stage. Furthermore, PTEN mutation also causes a variety of inherited predispositions to cancer.
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ImmunogenRecombinant full-length human protein was used as the immunogen for the PTEN antibody.
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StorageStore the PTEN antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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LocalizationCytoplasmic and nuclear
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PropertiesIf you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolPTEN, PTENP1
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Short nameAnti-PTEN
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit IgG
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Alternative nameAntibodies to PTEN
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Alternative techniqueantibodies
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Alternative to gene targetphosphatase and tensin homolog, 10q23del and BZS and CWS1 and DEC and GLM2 and MHAM and MMAC1 and PTEN1 and TEP1, PTEN and IDBG-81409 and ENSG00000171862 and 5728, phosphatidylinositol-3, nuclei, Pten and IDBG-158878 and ENSMUSG00000013663 and 19211, PTEN and IDBG-637256 and ENSBTAG00000009498 and 540786
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Gene info
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Identity
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Gene
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Long gene namephosphatase and tensin homolog
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Synonyms gene
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1997-04-21
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- PTEN protein phosphatases
- C2 tensin-type domain containing
- Phosphoinositide phosphatases
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namephosphatase and tensin homolog pseudogene 1
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Synonyms gene name
- phosphatase and tensin homolog pseudogene 1 (functional)
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-09-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
