PTBP1 Antibody

• Catalog number
  F47514-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  PTBP1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the PTBP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This PTBP1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P26599
• Purity
  Antigen affinity
• Description
  This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
• Immunogen
  A portion of amino acids 26-55 from the human protein was used as the immunogen for this PTBP1 antibody.
• Storage
  Aliquot the PTBP1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PTBP1  
• Gene symbol
  PTBP1
• Short name
  Anti-PTBP1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to PTBP1
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9583
• Gene
  PTBP1
• Long gene name
  polypyrimidine tract binding protein 1
• Synonyms gene
  • PTB
• Synonyms gene name
  • polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I)
• Synonyms
  • HNRPI
  • HNRNP-I
  • PTB2
  • PTB3
  • PTB-1
  • PTB4
  • pPTB
• Synonyms name
  • heterogeneous nuclear ribonucleoprotein I
• GenBank acession
  • X60648
• Locus
  19p13.3
• Discovery year
  1992-06-29
• Entrez gene record
  5725
• Pubmed identfication
  • 1906036
  • 11024286
• RefSeq identity
  • NM_002819
• Classification
  • RNA binding motif containing
  • Heterogeneous nuclear ribonucleoproteins
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000181789

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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