p300 Antibody (KAT3B)

• Catalog number
  R31592
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  p300 (KAT3B)
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the p300 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This p300 antibodyis to be used only for research purposes and not for diagnostics..
• Gene ID
  2033
• Purity
  Antigen affinity
• Description
  E1A binding protein p300 is a protein that in humans is encoded by the EP300 gene. The gene is located on the long (q) arm of the human chromosome 22 at position 13.2. This protein regulates the activity of many genes in tissues throughout the body. It plays an essential role in regulating cell growth and division, prompting cells to mature and assume specialized functions (differentiate), and preventing the growth of cancerous tumors. p300 appears to be critical for normal development before and after birth. It carries out its function by activating transcription. In addition, the protein functions as histone acetyltransferase that regulates transcription via chromatin remodeling, and is important in the processes of cell proliferation and differentiation. p300 also mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein.
• Immunogen
  Human partial recombinant protein (AA 2065-2414) was used as the immunogen for this KAT3B / p300 antibody.
• Storage
  After reconstitution, the p300 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Localization
  Intracellular
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  p300   KAT3B  
• Gene symbol
  EP300
• Short name
  Anti-p300 (KAT3B)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to p300 (KAT3B)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3373
• Gene
  EP300
• Long gene name
  E1A binding protein p300
• Synonyms
  • p300
  • KAT3B
• Synonyms name
  • histone acetyltransferase p300
• GenBank acession
  • U01877
• Locus
  22q13.2
• Discovery year
  1998-07-31
• Entrez gene record
  2033
• Pubmed identfication
  • 7523245
• RefSeq identity
  • NM_001429
• Classification
  • Zinc fingers ZZ-type
  • Lysine acetyltransferases
  • Bromodomain containing
• VEGA ID
  OTTHUMG00000150937
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_1422

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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