OPA1 Antibody
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Catalog numberR31823
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PricePlease ask
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Size0.1mg
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CategoryAntibody
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Concentration0.5mg/ml if reconstituted with 0.2ml sterile DI water
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FormAntigen affinity purified
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ConjugationUnconjugated
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ClonePolyclonal antibody
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Recognised antigenOPA1
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Host animalRabbit (Oryctolagus cuniculus)
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ClonalityPolyclonal (rabbit origin)
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Species reactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
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Tested applicationsWB, IHC-P
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Recommended dilutionsWestern blot: 0.1-0.5ug/ml,IHC (Paraffin): 0.5-1ug/ml
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NotesOptimal dilution of the OPA1 antibody should be determined by the researcher.
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Intented useThis OPA1 antibodyis to be used only for research purposes and not for diagnostics..
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UniprotO60313
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PurityAntigen affinity
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DescriptionDynamin-like 120 kDa protein, mitochondrial is a protein that in humans is encoded by the OPA1 gene. It is mapped to 3q29. This protein regulates mitochondrial fusion and cristae structure in the inner mitochondrial membrane (IMM) and contributes to ATP synthesis and apoptosis. This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
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ImmunogenAmino acids EDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEA of human OPA1 were used as the immunogen for the OPA1 antibody.
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StorageAfter reconstitution, the OPA1 antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
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LocalizationCytoplasmic, membrane
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PropertiesIf you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolOPA1-AS1, OPA1, MED12
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Short nameAnti-OPA1
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit IgG
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Alternative nameAntibodies to OPA1
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Alternative techniqueantibodies
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Alternative to gene targetoptic atrophy 1 (autosomal dominant), largeG and MGM1 and NPG and NTG, OPA1 and IDBG-70072 and ENSG00000198836 and 4976, GTP binding, Plasma membranes, Opa1 and IDBG-151468 and ENSMUSG00000038084 and 74143, OPA1 and IDBG-634327 and ENSBTAG00000019514 and 524142
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Gene info
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Identity
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Gene
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Long gene nameOPA1 antisense RNA 1
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Synonyms gene name
- OPA1 antisense RNA 1 (non-protein coding)
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Locus
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Discovery year2011-07-27
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Entrez gene record
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Classification
- Antisense RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameOPA1 mitochondrial dynamin like GTPase
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Synonyms gene name
- optic atrophy 1 (autosomal dominant)
- OPA1, mitochondrial dynamin like GTPase
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1987-09-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemediator complex subunit 12
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Synonyms gene
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Synonyms gene name
- trinucleotide repeat containing 11 (THR-associated protein, 230kDa subunit)
- mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae)
- FG syndrome 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2000-01-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Mediator complex
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data