Oncostatin M Antibody / OSM

• Catalog number
  R31961
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Oncostatin M / OSM
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P, ELISA
• Recommended dilutions
  Western blot: 0.1-0.5ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  Optimal dilution of the OSM antibody should be determined by the researcher.
• Intented use
  This OSM antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P13725
• Purity
  Antigen affinity
• Description
  Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. The OSM gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. It has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts. Treatment with recombinant Oncostatin M leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types. Oncostatin M also has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells, a function shared by LIF, CSF3, and IL6. The direction of gene transcription was telomeric to centromeric, with the OSM gene located upstream of the LIF gene.
• Immunogen
  Amino acids 26-220 of human Oncostatin M were used as the immunogen for the OSM antibody.
• Storage
  After reconstitution, the OSM antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Localization
  Nuclear, cytoplasmic
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Oncostatin   OSM  
• Gene symbol
  OSM, CCM2, IFT172, KIF17
• Short name
  Anti-Oncostatin M / OSM
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to Oncostatin M / OSM
• Alternative technique
  antibodies
• Alternative to gene target
  oncostatin M, OSM and IDBG-4002 and ENSG00000099985 and 5008, growth factor activity, Extracellular, Osm and IDBG-142284 and ENSMUSG00000058755 and 18413, BT.45038 and IDBG-636338 and ENSBTAG00000016163 and 319086

Gene info

• Identity
  HGNC:8506
• Gene
  OSM
• Long gene name
  oncostatin M
• Synonyms
  • MGC20461
• GenBank acession
  • AF129855
• Locus
  22q12.2
• Discovery year
  1992-07-09
• Entrez gene record
  5008
• Pubmed identfication
  • 1717982
• RefSeq identity
  • NM_020530
• Classification
  • Interleukin 6 type cytokine family
• VEGA ID
  OTTHUMG00000150913

Gene info

• Identity
  HGNC:21708
• Gene
  CCM2
• Long gene name
  CCM2 scaffold protein
• Synonyms gene
  • C7orf22
• Synonyms gene name
  • chromosome 7 open reading frame 22
  • cerebral cavernous malformation 2
  • CCM2 scaffolding protein
• Synonyms
  • MGC4607
  • OSM
• Synonyms name
  • malcavernin
  • osmosensing scaffold for MEKK3
• GenBank acession
  • BC004903
• Locus
  7p13
• Discovery year
  2003-07-14
• Entrez gene record
  83605
• Pubmed identfication
  • 9811928
• RefSeq identity
  • NM_031443
• Classification
  • CCM adhesion complex
• VEGA ID
  OTTHUMG00000129246
• Locus Specific Databases
  • LRG_664

Gene info

• Identity
  HGNC:30391
• Gene
  IFT172
• Long gene name
  intraflagellar transport 172
• Synonyms gene name
  • intraflagellar transport 172 homolog (Chlamydomonas)
• Synonyms
  • SLB
  • wim
  • osm-1
  • NPHP17
  • BBS20
• Synonyms name
  • wimple homolog
• GenBank acession
  • AB033005
• Locus
  2p23.3
• Discovery year
  2005-11-02
• Entrez gene record
  26160
• Pubmed identfication
  • 10788441
  • 10574461
  • 24140113
  • 26763875
• RefSeq identity
  • NM_015662
• Classification
  • WD repeat domain containing
  • IFT-B2 complex
• VEGA ID
  OTTHUMG00000128425

Gene info

• Identity
  HGNC:19167
• Gene
  KIF17
• Long gene name
  kinesin family member 17
• Synonyms
  • KIAA1405
  • KIF3X
  • KIF17B
  • OSM-3
  • KLP-2
• Synonyms name
  • kinesin-like protein KIF17
  • KIF3-related motor protein
  • KIF17 variant protein
• GenBank acession
  • AB037826
• Locus
  1p36.12
• Discovery year
  2002-08-29
• Entrez gene record
  57576
• Pubmed identfication
  • 10846156
• RefSeq identity
  • NM_020816
• Classification
  • Kinesins
• VEGA ID
  OTTHUMG00000002863

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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