NRP2 Antibody

• Catalog number
  R30864
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  NRP2
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the NRP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This NRP2 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  O60462
• Purity
  Antigen affinity
• Description
  Neuropilin-2, also called Npn2 or VEGF165R2, is a member of the neuropilin family of receptor proteins. Sema3b can act to repulse axons expressing neuropilin-2 and can antagonize the repulsive action of Sema3a on axonal growth cones expressing neuropilin-1. NRP2 may play a role in cardiovascular development, axon guidance, and tumorigenesis. Mice with null mutations in genes encoding Sema3F, and its holoreceptor components NRP2 and Plexin A3 (PLEXA3) exhibit increased dentate gyrus granule cell and cortical layer V pyramidal neuron spine number and size, and also aberrant spine distribution. Moreover, Sema3F promotes loss of spines and excitatory synapses in dissociated neurons in vitro, and in NRP2-null brain slices cortical layer V and dentate gyrus granule cells exhibit increased miniature excitatory postsynaptic current frequency. These disparate effects of secreted semaphorins are reflected in the restricted dendritic localization of Neuropilin-2 to apical dendrites and of NRP1 to all dendrites of cortical pyramidal neurons.
• Immunogen
  Amino acids 45-60 (YPQDYPSHQNCEWIVY-human) were used as the immunogen for this NRP2 antibody (100% mouse homology).
• Storage
  After reconstitution, the NRP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  NRP2  
• Gene symbol
  NELL2, NRP2
• Short name
  Anti-NRP2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to NRP2
• Alternative technique
  antibodies
• Alternative to gene target
  neuropilin 2, NP2 and NPN2 and PRO2714 and VEGF165R2, NRP2 and IDBG-79320 and ENSG00000118257 and 8828, metal ion binding, Extracellular, Nrp2 and IDBG-160044 and ENSMUSG00000025969 and 18187, NRP2 and IDBG-643390 and ENSBTAG00000011971 and 541004

Gene info

• Identity
  HGNC:7751
• Gene
  NELL2
• Long gene name
  neural EGFL like 2
• Synonyms gene name
  • nel (chicken)-like 2
  • NEL-like 2 (chicken)
• Synonyms
  • NRP2
• GenBank acession
  • D83018
• Locus
  12q12
• Discovery year
  1996-07-17
• Entrez gene record
  4753
• Pubmed identfication
  • 8975702
  • 25537860
• RefSeq identity
  • NM_006159
• VEGA ID
  OTTHUMG00000169464

Gene info

• Identity
  HGNC:8005
• Gene
  NRP2
• Long gene name
  neuropilin 2
• Synonyms
  • VEGF165R2
• GenBank acession
  • AF016098
• Locus
  2q33.3
• Discovery year
  1998-12-23
• Entrez gene record
  8828
• Pubmed identfication
  • 9529250
  • 9331348
• VEGA ID
  OTTHUMG00000132893

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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