MKK4 Antibody MEK4

• Catalog number
  R31399
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  MKK4 MEK4
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the MKK4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This MKK4 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P45985
• Purity
  Antigen affinity
• Description
  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4), also called MEK4, SEK1, JNKK1 and MKK4, is an enzyme that in humans is encoded by the MAP2K4 gene. It is mapped to 17p12. This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK1. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. MAP2K4 was a specific activator of JNK1, JNK2, and p38, and it has been shown to interact with FLNC, MAPK8, MAPK8IP3 and AKT1.
• Immunogen
  An amino acid sequence from the C-terminus of human MKK4/MEK4 (ELLKHPFILMYEERAVEVA) was used as the immunogen for this MKK4 antibody.
• Storage
  After reconstitution, the MKK4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MKK4   MEK4  
• Gene symbol
  MAP2K4
• Short name
  Anti-MKK4 MEK4
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to MKK4 MEK4
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6844
• Gene
  MAP2K4
• Long gene name
  mitogen-activated protein kinase kinase 4
• Synonyms gene
  • SERK1
• Synonyms
  • MEK4
  • JNKK1
  • PRKMK4
  • MKK4
• GenBank acession
  • L36870
• Locus
  17p12
• Discovery year
  1997-11-11
• Entrez gene record
  6416
• Pubmed identfication
  • 7716521
• Classification
  • Mitogen-activated protein kinase kinases
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000178267

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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