MGP Antibody / Matrix Gla protein

• Catalog number
  R32430
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  MGP / Matrix Gla protein
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.1-0.5ug/ml,IHC (FFPE): 0.5-1ug/ml
• Notes
  Optimal dilution of the MGP antibody should be determined by the researcher.
• Intented use
  This MGP antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P08493
• Purity
  Antigen affinity
• Description
  Matrix Gla protein (MGP) is an 84-residue vitamin K-dependent protein initially isolated from bovine bone. In addition, MGP is a 10-kD protein produced and secreted by vascular smooth muscle cells and chondrocytes and significantly accumulated in bone, cartilage, and dentin. It is also expressed at high levels in heart, kidney, and lung and is upregulated by vitamin D in bone cells. MGP has a high affinity binding to calcium ions, similar to other Gla-containing proteins. The protein acts as an inhibitor of vascular mineralization and plays a role in bone organization. And this gene is mapped to 12p12.3.
• Immunogen
  Amino acids Y20-F96 from the human protein were used as the immunogen for the MGP antibody.
• Storage
  After reconstitution, the MGP antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Localization
  Cytoplasmic, membranous
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MGP   Matrix   Gla   protein  
• Gene symbol
  MGP
• Short name
  Anti-MGP / Matrix Gla protein
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to MGP / Matrix Gla protein
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:7060
• Gene
  MGP
• Long gene name
  matrix Gla protein
• GenBank acession
  • M58549
• Locus
  12p12.3
• Discovery year
  1991-08-01
• Entrez gene record
  4256
• Pubmed identfication
  • 2394711
• RefSeq identity
  • NM_000900
• Classification
  • Gla domain containing
• VEGA ID
  OTTHUMG00000168740

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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