MARK1 Antibody

• Catalog number
  F40144-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  MARK1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  IHC, WB, ELISA
• Recommended dilutions
  Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
• Notes
  Titration of the MARK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This MARK1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q9P0L2
• Purity
  Purified
• Description
  MARK is a family of kinases that is known for its involvement in establishing cell polarity and in phosphorylating tau protein during Alzheimer neurodegeneration. Expression of MARK causes the phosphorylation of MAPs at their KXGS motifs, thereby detaching MAPs from the microtubules and thus facilitating the transport of particles. This occurs without impairing the intrinsic activity of motors because the velocity during active movement remains unchanged. In primary retinal ganglion cells, transfection with tau leads to the inhibition of axonal transport of mitochondria, APP vesicles, and other cell components which leads to starvation of axons and vulnerability against stress. This transport inhibition can be rescued by phosphorylating tau with MARK
• Immunogen
  A portion of amino acids 6-40 from the human protein was used as the immunogen for this MARK1 antibody.
• Storage
  Aliquot the MARK1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MARK1  
• Gene symbol
  MARK1
• Short name
  Anti-MARK1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to MARK1
• Alternative technique
  antibodies
• Alternative to gene target
  MAP/microtubule affinity-regulating kinase 1, MARK and Par-1c and Par1c, MARK1 and IDBG-106753 and ENSG00000116141 and 4139, phosphatidylinositol-4, Plasma membranes, Mark1 and IDBG-207919 and ENSMUSG00000026620 and 226778

Gene info

• Identity
  HGNC:6896
• Gene
  MARK1
• Long gene name
  microtubule affinity regulating kinase 1
• Synonyms gene name
  • MAP/microtubule affinity-regulating kinase 1
• Synonyms
  • MARK
  • PAR-1C
• GenBank acession
  • AF154845
• Locus
  1q41
• Discovery year
  1997-10-27
• Entrez gene record
  4139
• Pubmed identfication
  • 9108484
• VEGA ID
  OTTHUMG00000037351

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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