MALT1 Antibody

• Catalog number
  R31020
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  MALT1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the MALT1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This MALT1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q9UDY8
• Purity
  Antigen affinity
• Description
  Mucosa-associated lymphoid tissue lymphoma translocation protein 1, also called MLT or Paracaspase, is a protein that in humans is encoded by the MALT1 gene. This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3(also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. Dierlamm et al.(1999) and Akagi et al.(1999) mapped the gene to chromosome 18q21. Using mouse models, Ruland et al.(2003) demonstrated that MALT1 is essential for T-cell activation, proliferation, and IL2 production in response to T-cell receptor ligation and strictly required for signal-specific NF-kappa-B(NFKB) activation induced by the T-cell receptor but not TNF-alpha or IL1 signaling. MALT1 operates downstream of BCL10, controls the catalytic activity of the canonical I-kappa-B kinase complex, and regulates the signaling of JNK and p38 MAP kinases.
• Immunogen
  An amino acid sequence from the C-terminus of human MALT1 (DEIPFSFSDRLRISEK) was used as the immunogen for this MALT1 antibody.
• Storage
  After reconstitution, the MALT1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MALT1  
• Gene symbol
  MALT1-AS1, MALT1
• Short name
  Anti-MALT1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to MALT1
• Alternative technique
  antibodies
• Alternative to gene target
  mucosa associated lymphoid tissue lymphoma translocation gene 1, IMD12 and MLT and MLT1, MALT1 and IDBG-3930 and ENSG00000172175 and 10892, protein self-association, nuclei, Malt1 and IDBG-154592 and ENSMUSG00000032688 and 240354, MALT1 and IDBG-644866 and ENSBTAG00000027916 and 504994

Gene info

• Identity
  HGNC:55306
• Gene
  MALT1-AS1
• Long gene name
  MALT1 antisense RNA 1
• Locus
  18q21.32
• Discovery year
  2020-10-16
• Entrez gene record
  101927322
• RefSeq identity
  • NR_164150
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:6819
• Gene
  MALT1
• Long gene name
  MALT1 paracaspase
• Synonyms gene
  • MLT
• Synonyms gene name
  • mucosa associated lymphoid tissue lymphoma translocation gene 1
• Synonyms
  • PCASP1
• Synonyms name
  • MALT1 protease
  • paracaspase 1
• Locus
  18q21.32
• Discovery year
  1999-08-02
• Entrez gene record
  10892
• Pubmed identfication
  • 10339464
  • 10406266
  • 10523859
  • 11090634
  • 26377317
• RefSeq identity
  • NM_006785
• Classification
  • Immunoglobulin like domain containing
  • CBM complex
• VEGA ID
  OTTHUMG00000132761
• Locus Specific Databases
  • LRG_1221

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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