Lats2 Antibody

• Catalog number
  F47336-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Lats2
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the Lats2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This Lats2 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q7TSJ6
• Purity
  Antigen affinity
• Description
  Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor (By similarity).
• Immunogen
  A portion of amino acids 1000-1027 from the mouse protein was used as the immunogen for this Lats2 antibody.
• Storage
  Aliquot the Lats2 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Lats2  
• Gene symbol
  LATS2-AS1, LATS2
• Short name
  Anti-Lats2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to Lats2
• Alternative technique
  antibodies
• Alternative to gene target
  LATS, large tumor suppressor, homolog 2 (Drosophila), LATS2 and IDBG-13987 and ENSG00000150457 and 26524, transferase activity, nuclei, Lats2 and IDBG-168883 and ENSMUSG00000021959 and 50523, LATS2 and IDBG-631161 and ENSBTAG00000014406 and

Gene info

• Identity
  HGNC:39912
• Gene
  LATS2-AS1
• Long gene name
  LATS2 antisense RNA 1
• Synonyms gene name
  • LATS2 antisense RNA 1 (non-protein coding)
• Locus
  13q12.11
• Discovery year
  2011-04-11
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000016527

Gene info

• Identity
  HGNC:6515
• Gene
  LATS2
• Long gene name
  large tumor suppressor kinase 2
• Synonyms gene name
  • LATS (large tumor suppressor, Drosophila) homolog 2
  • LATS, large tumor suppressor, homolog 2 (Drosophila)
• GenBank acession
  • AB028019
• Locus
  13q12.11
• Discovery year
  1999-12-07
• Entrez gene record
  26524
• Pubmed identfication
  • 10673337
• Classification
  • AGC family kinases
• VEGA ID
  OTTHUMG00000016531

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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