Integrin linked kinase Antibody (ILK)
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Catalog number
R32407
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Price
Please ask
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Size
0.1mg
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Category
Antibody
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Concentration
0.5mg/ml if reconstituted with 0.2ml sterile DI water
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Form
Antigen affinity purified
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Conjugation
Unconjugated
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Clone
Polyclonal antibody
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Recognised antigen
Integrin linked kinase (ILK)
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Host animal
Rabbit (Oryctolagus cuniculus)
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Clonality
Polyclonal (rabbit origin)
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Species reactivity
Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
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Tested applications
WB
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Recommended dilutions
Western blot: 0.1-0.5ug/ml
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Notes
Optimal dilution of the Integrin linked kinase antibody should be determined by the researcher.
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Intented use
This Integrin linked kinase antibodyis to be used only for research purposes and not for diagnostics..
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Uniprot
Q13418
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Purity
Antigen affinity
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Description
ILK, also known as Integrin-linked kinase, is a serine-threonine protein kinase. Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK) interacts with the cytoplasmic domain of beta-1 integrin. This gene was initially described to encode a serine/ threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. Recent results showed that ILK contains 5 ankyrin-like repeats, and that the C-terminal kinase domain is actually a pseudo-kinase with adaptor function.
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Immunogen
Amino acids M1-H203 from the human protein were used as the immunogen for the Integrin linked kinase antibody.
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Storage
After reconstitution, the Integrin linked kinase antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
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Localization
Cytoplasmic
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Properties
If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
ILK
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Short name
Anti-Integrin linked kinase (ILK)
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Technique
Antibody, antibodies against human proteins, antibodies for
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Isotype
Rabbit IgG
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Alternative name
Antibodies to Integrin linked kinase (ILK)
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Alternative technique
antibodies
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Alternative to gene target
integrin-linked kinase, HEL-S-28 and ILK-1 and ILK-2 and P59 and p59ILK, ILK and IDBG-29381 and ENSG00000166333 and 3611, transferase activity, nuclei, Ilk and IDBG-204955 and ENSMUSG00000030890 and 16202, ILK and IDBG-634121 and ENSBTAG00000000696 and 540207
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Gene info
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Identity
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Gene
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Long gene name
integrin linked kinase
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Synonyms gene name
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GenBank acession
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Locus
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Discovery year
1997-05-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Ankyrin repeat domain containing
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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