GNAS Antibody (G protein alpha S)

• Catalog number
  F40026-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS pH 7.4 with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  GNAS (G protein alpha S)
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC, IF, FACS, ELISA
• Recommended dilutions
  Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50,Flow Cytometry: 1:10-1:50
• Notes
  Titration of the GNAS antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This GNAS antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q5FWY2
• Purity
  Antigen affinity
• Description
  Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
• Immunogen
  A portion of amino acids 287-315 from the human protein was used as the immunogen for this GNAS antibody.
• Storage
  Aliquot the GNAS antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Additional description
  The Anti-GNAS (G protein alpha S) is a α- or alpha protein sometimes glycoprotein present in blood.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  GNAS   protein   alpha  
• Gene symbol
  GNAS-AS1, GNAS
• Short name
  Anti-GNAS (G protein alpha S)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to GNAS (G protein alpha S)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:24872
• Gene
  GNAS-AS1
• Long gene name
  GNAS antisense RNA 1
• Synonyms gene
  • GNASAS
  • GNAS-AS
• Synonyms gene name
  • GNAS antisense RNA (non-protein coding)
  • GNAS antisense RNA 1 (non-protein coding)
• Synonyms
  • SANG
  • NESP-AS
  • NESPAS
  • GNAS1AS
  • NCRNA00075
• Synonyms name
  • GNAS antisense
  • non-protein coding RNA 75
• GenBank acession
  • AJ251759
• Locus
  20q13.32
• Discovery year
  2008-06-20
• Entrez gene record
  149775
• Pubmed identfication
  • 10749992
• RefSeq identity
  • NR_002785
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000060481
• Locus Specific Databases
  • LRG_1051

Gene info

• Identity
  HGNC:4392
• Gene
  GNAS
• Long gene name
  GNAS complex locus
• Synonyms gene
  • GNAS1
• Synonyms gene name
  • guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1
• Synonyms
  • NESP55
  • NESP
  • GNASXL
  • GPSA
  • SCG6
  • SgVI
• Synonyms name
  • secretogranin VI
  • G protein subunit alpha S
• GenBank acession
  • M21142
• Locus
  20q13.32
• Discovery year
  1990-06-29
• Entrez gene record
  2778
• RefSeq identity
  • NM_000516
• Classification
  • G protein subunits alpha, group s
  • Granins
• VEGA ID
  OTTHUMG00000033069
• Locus Specific Databases
  • LOVD - Leiden Open Variation Database

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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