GNAS Antibody (G protein alpha S)
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Catalog numberF40026-0.08ML
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PricePlease ask
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Size0.08 ml
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CategoryAntibody
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ConcentrationIn 1X PBS pH 7.4 with 0.09% sodium azide
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FormAntigen affinity purified
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ConjugationUnconjugated
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ClonePolyclonal antibody
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Recognised antigenGNAS (G protein alpha S)
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Host animalRabbit (Oryctolagus cuniculus)
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ClonalityPolyclonal (rabbit origin)
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Species reactivityHuman (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
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Tested applicationsWB, IHC, IF, FACS, ELISA
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Recommended dilutionsWestern blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50,Flow Cytometry: 1:10-1:50
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NotesTitration of the GNAS antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Intented useThis GNAS antibodyis to be used only for research purposes and not for diagnostics..
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UniprotQ5FWY2
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PurityAntigen affinity
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DescriptionGuanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
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ImmunogenA portion of amino acids 287-315 from the human protein was used as the immunogen for this GNAS antibody.
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StorageAliquot the GNAS antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
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Additional descriptionThe Anti-GNAS (G protein alpha S) is a α- or alpha protein sometimes glycoprotein present in blood.
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PropertiesIf you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolGNAS-AS1, GNAS
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Short nameAnti-GNAS (G protein alpha S)
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit Ig
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Alternative nameAntibodies to GNAS (G protein alpha S)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameGNAS antisense RNA 1
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Synonyms gene
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Synonyms gene name
- GNAS antisense RNA (non-protein coding)
- GNAS antisense RNA 1 (non-protein coding)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2008-06-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Antisense RNAs
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameGNAS complex locus
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Synonyms gene
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Synonyms gene name
- guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1990-06-29
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Entrez gene record
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RefSeq identity
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Classification
- G protein subunits alpha, group s
- Granins
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data