Glucocorticoid receptor Antibody

• Catalog number
  R31645
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Glucocorticoid receptor
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the Glucocorticoid receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This Glucocorticoid receptor antibodyis to be used only for research purposes and not for diagnostics..
• Gene ID
  2908
• Purity
  Antigen affinity
• Description
  The glucocorticoid receptor (GR, or GCR), also known as NR3C1, is the receptor to which cortisol and other glucocorticoids bind. In humans, the GR protein is encoded by NR3C1 gene which is located on chromosome 5 (5q31). GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. Because the receptor is expressed in several forms, it has many different effects in different parts of the body. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol (by preventing the translocation of other transcription factors from the cytosol into the nucleus).
• Immunogen
  Partial recombinant human NR3C1 protein (AA 1-373) was used as the immunogen for this Glucocorticoid receptor antibody.
• Storage
  After reconstitution, the Glucocorticoid receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Localization
  Nuclear
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Additional description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• French translation
  anticorps

• Gene target
  Glucocorticoid   receptor  
• Gene symbol
  NR3C1, NCOA2, ARHGAP35
• Short name
  Anti-Glucocorticoid receptor
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to Glucocorticoid receptor
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:7978
• Gene
  NR3C1
• Long gene name
  nuclear receptor subfamily 3 group C member 1
• Synonyms gene
  • GRL
• Synonyms gene name
  • nuclear receptor subfamily 3, group C, member 1
  • nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
• Synonyms
  • GR
• Synonyms name
  • glucocorticoid receptor
• GenBank acession
  • X03225
• Locus
  5q31.3
• Discovery year
  2001-06-22
• Entrez gene record
  2908
• Pubmed identfication
  • 2867473
• Classification
  • Nuclear receptor subfamily 3 group C
• VEGA ID
  OTTHUMG00000129677

Gene info

• Identity
  HGNC:7669
• Gene
  NCOA2
• Long gene name
  nuclear receptor coactivator 2
• Synonyms
  • TIF2
  • GRIP1
  • NCoA-2
  • KAT13C
  • bHLHe75
• Synonyms name
  • glucocorticoid receptor interacting protein 1
• GenBank acession
  • X97674
• Locus
  8q13.3
• Discovery year
  1999-12-17
• Entrez gene record
  10499
• Pubmed identfication
  • 9111344
  • 8670870
• Classification
  • Lysine acetyltransferases
  • Basic helix-loop-helix proteins
• VEGA ID
  OTTHUMG00000164671

Gene info

• Identity
  HGNC:4591
• Gene
  ARHGAP35
• Long gene name
  Rho GTPase activating protein 35
• Synonyms gene
  • GRLF1
• Synonyms gene name
  • glucocorticoid receptor DNA binding factor 1
• Synonyms
  • GRF-1
  • p190ARhoGAP
  • P190A
  • KIAA1722
  • p190RhoGAP
• GenBank acession
  • M73077
• Locus
  19q13.32
• Discovery year
  1993-12-15
• Entrez gene record
  2909
• Pubmed identfication
  • 1894621
  • 20675588
• RefSeq identity
  • NM_004491
• Classification
  • Rho GTPase activating proteins
• VEGA ID
  OTTHUMG00000183438

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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