Furin Antibody

• Catalog number
  R31596
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Furin
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the Furin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This Furin antibodyis to be used only for research purposes and not for diagnostics..
• Gene ID
  5045
• Purity
  Antigen affinity
• Description
  Furin (Fur), also known as PACE, is a protein that in humans is encoded by the FURIN gene. The protein encoded by this gene is an enzyme which belongs to the subtilisin-like proprotein convertase family. The gene is located approximately 1 kb upstream of the FES gene on chromosome 15q25-q26. Furin is thought to play a role in tumor progression. It is one of the proteases responsible for the proteolytic cleavage of HIV envelope polyprotein precursor gp160 to gp120 and gp41 prior to viral assembly. Furin is enriched in the Golgi apparatus, where it functions to cleave other proteins into their mature/active forms. Expression in T-cells is required for maintenance of peripheral immune tolerance.
• Immunogen
  Human partial recombinant protein (AA 591-794) was used as the immunogen for this Furin antibody.
• Storage
  After reconstitution, the Furin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Furin  
• Gene symbol
  FURIN
• Short name
  Anti-Furin
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to Furin
• Alternative technique
  antibodies
• Alternative to gene target
  furin (paired basic amino acid cleaving enzyme), FUR and PACE and PCSK3 and SPC1, FURIN and IDBG-30430 and ENSG00000140564 and 5045, nerve growth factor binding, Cell surfaces, Furin and IDBG-195335 and ENSMUSG00000030530 and 18550, FURIN and IDBG-629479 and ENSBTAG00000002939 and 281374

Gene info

• Identity
  HGNC:8568
• Gene
  FURIN
• Long gene name
  furin, paired basic amino acid cleaving enzyme
• Synonyms gene
  • PCSK3
  • FUR
  • PACE
• Synonyms gene name
  • paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein)
  • furin (paired basic amino acid cleaving enzyme)
• Synonyms
  • SPC1
• Synonyms name
  • proprotein convertase subtilisin/kexin 3
  • subtilisin-like proprotein convertase 1
• GenBank acession
  • X17094
• Locus
  15q26.1
• Discovery year
  1991-08-08
• Entrez gene record
  5045
• Pubmed identfication
  • 2251280
  • 1741956
• RefSeq identity
  • NM_002569
• Classification
  • Proprotein convertase subtilisin/kexin family
• VEGA ID
  OTTHUMG00000149831

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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