FMRP Antibody / FMR1

• Catalog number
  R32195
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  FMRP / FMR1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.1-0.5ug/ml
• Notes
  Optimal dilution of the FMRP antibody should be determined by the researcher.
• Intented use
  This FMRP antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q06787
• Purity
  Antigen affinity
• Description
  FMR1 (fragile X mental retardation 1) is a human gene that codes for a protein called fragile X mental retardation protein, or FMRP. This protein, most commonly found in the brain, is essential for normalcognitive developmentand female reproductive function. Mutations of this gene can lead to fragile X syndrome, mental retardation, premature ovarian failure, autism, Parkinson's disease, developmental delays and other cognitive deficits. The protein encoded by this gene binds RNA and is associated with polysomes. Additionally, the encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
• Immunogen
  Amino acids ENYQLVILSINEVTSKRAHMLIDMHFRSLRTKLSLIM of human FMRP were used as the immunogen for the FMRP antibody.
• Storage
  After reconstitution, the FMRP antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  FMRP   FMR1  
• Gene symbol
  FMR1, FMR1-IT1, FMR1-AS1
• Short name
  Anti-FMRP / FMR1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to FMRP / FMR1
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3775
• Gene
  FMR1
• Long gene name
  FMRP translational regulator 1
• Synonyms gene
  • POF1
  • POF
• Synonyms gene name
  • premature ovarian failure 1
  • fragile X mental retardation 1
• Synonyms
  • FMRP
  • FRAXA
  • MGC87458
• GenBank acession
  • X69962
• Locus
  Xq27.3
• Discovery year
  1992-01-17
• Entrez gene record
  2332
• Pubmed identfication
  • 1572655
• RefSeq identity
  • NM_002024
• VEGA ID
  OTTHUMG00000022606
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_762

Gene info

• Identity
  HGNC:41333
• Gene
  FMR1-IT1
• Long gene name
  FMR1 intronic transcript 1
• Synonyms gene name
  • FMR1 intronic transcript 1 (non-protein coding)
• Locus
  Xq27.3
• Discovery year
  2011-05-19
• Classification
  • Intronic transcripts
• VEGA ID
  OTTHUMG00000046184

Gene info

• Identity
  HGNC:39081
• Gene
  FMR1-AS1
• Long gene name
  FMR1 antisense RNA 1
• Synonyms gene
  • FMR1AS
  • FMR1-AS
• Synonyms gene name
  • FMR1 antisense RNA (non-protein coding)
  • FMR1 antisense RNA 1 (non-protein coding)
  • FMR1 antisense RNA 1 (head to head)
• Synonyms
  • ASFMR1
  • FMR4
• Synonyms name
  • antisense fragile X mental retardation protein
• Locus
  Xq27.3
• Discovery year
  2010-10-05
• Entrez gene record
  100126270
• Pubmed identfication
  • 17921506
  • 18213394
• RefSeq identity
  • NR_024499
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000182466

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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