Filaggrin Antibody

• Catalog number
  R32006
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Filaggrin
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.1-0.5ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  Optimal dilution of the Filaggrin antibody should be determined by the researcher.
• Intented use
  This Filaggrin antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P20930
• Purity
  Antigen affinity
• Description
  In humans, profillagrin is encoded by the FLG gene, which is part of the S100 fused-type protein (SFTP) family within the epidermal differentiation complex on chromosome 1q21. The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.
• Immunogen
  Amino acids 1-261 of human Filaggrin were used as the immunogen for the Filaggrin antibody.
• Storage
  After reconstitution, the Filaggrin antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Filaggrin  
• Gene symbol
  FLG2, FLG, HRNR
• Short name
  Anti-Filaggrin
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to Filaggrin
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:33276
• Gene
  FLG2
• Long gene name
  filaggrin 2
• Synonyms gene name
  • filaggrin family member 2
• Synonyms
  • IFPS
• Synonyms name
  • ifapsoriasin
• GenBank acession
  • AY827490
• Locus
  1q21.3
• Discovery year
  2007-08-21
• Entrez gene record
  388698
• Pubmed identfication
  • 19384417
• RefSeq identity
  • NM_001014342
• Classification
  • S100 fused type protein family
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000012245

Gene info

• Identity
  HGNC:3748
• Gene
  FLG
• Long gene name
  filaggrin
• Locus
  1q21.3
• Discovery year
  1989-10-18
• Entrez gene record
  2312
• Pubmed identfication
  • 2740331
  • 2248957
  • 16444271
• RefSeq identity
  • NM_002016
• Classification
  • S100 fused type protein family
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000012202
• Locus Specific Databases
  • LRG_1028

Gene info

• Identity
  HGNC:20846
• Gene
  HRNR
• Long gene name
  hornerin
• Synonyms
  • S100a18
  • S100A16
  • FLG3
• Synonyms name
  • filaggrin family member 3
• GenBank acession
  • AB104446
• Locus
  1q21.3
• Discovery year
  2004-10-05
• Entrez gene record
  388697
• Pubmed identfication
  • 15507446
• RefSeq identity
  • NM_001009931
• Classification
  • S100 fused type protein family
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000012243

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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