ERCC2 Antibody

• Catalog number
  F53151-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  ERCC2
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the ERCC2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This ERCC2 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P18074
• Purity
  Antigen affinity
• Description
  ATP-dependent 5'-3' DNA helicase, component of the core- TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.
• Immunogen
  This ERCC2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 687-722 amino acids from the C-terminal region of human ERCC2.
• Storage
  Aliquot the ERCC2 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ERCC2  
• Gene symbol
  ERCC2
• Short name
  Anti-ERCC2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to ERCC2
• Alternative technique
  antibodies
• Alternative to gene target
  excision repair cross-complementing rodent repair deficiency, complementation group 2, COFS2 and EM9 and TFIIH and TTD and XPD, ERCC2 and IDBG-57385 and ENSG00000104884 and 2068, hydrolase activity, nuclei, Ercc2 and IDBG-150400 and ENSMUSG00000030400 and 13871, ERCC2 and IDBG-639452 and ENSBTAG00000002072 and 100125238

Gene info

• Identity
  HGNC:3434
• Gene
  ERCC2
• Long gene name
  ERCC excision repair 2, TFIIH core complex helicase subunit
• Synonyms gene
  • XPD
• Synonyms gene name
  • xeroderma pigmentosum complementary group D
  • excision repair cross-complementing rodent repair deficiency, complementation group 2
  • excision repair cross-complementation group 2
• Synonyms
  • MAG
  • EM9
  • MGC102762
  • MGC126218
  • MGC126219
• Synonyms name
  • excision repair cross-complementing rodent repair deficiency, complementation group 2 protein
  • TFIIH basal transcription factor complex helicase XPB subunit
• Locus
  19q13.32
• Discovery year
  2001-06-22
• Entrez gene record
  2068
• Pubmed identfication
  • 8413672
  • 2184031
• RefSeq identity
  • NM_000400
• Classification
  • Xeroderma pigmentosum complementation groups
  • ERCC excision repair associated
  • DNA helicases
  • General transcription factor IIH complex subunits
• VEGA ID
  OTTHUMG00000048190
• Locus Specific Databases
  • The Globin Gene Server
  • LRG_461

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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