DUSP6 Antibody

• Catalog number
  F45736-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  DUSP6
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the DUSP6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This DUSP6 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q16828
• Purity
  Antigen affinity
• Description
  The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.
• Immunogen
  A portion of amino acids 59-88 from the human protein was used as the immunogen for this DUSP6 antibody.
• Storage
  Aliquot the DUSP6 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  DUSP6  
• Gene symbol
  DUSP6
• Short name
  Anti-DUSP6
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to DUSP6
• Alternative technique
  antibodies
• Alternative to gene target
  dual specificity phosphatase 6, HH19 and MKP3 and PYST1, DUSP6 and IDBG-50524 and ENSG00000139318 and 1848, MAP kinase tyrosine/serine/threonine phosphatase activity, nuclei, Dusp6 and IDBG-187794 and ENSMUSG00000019960 and 67603, DUSP6 and IDBG-630730 and ENSBTAG00000004587 and 515310

Gene info

• Identity
  HGNC:3072
• Gene
  DUSP6
• Long gene name
  dual specificity phosphatase 6
• Synonyms
  • MKP-3
  • PYST1
• GenBank acession
  • BC037236
• Locus
  12q21.33
• Discovery year
  1997-03-19
• Entrez gene record
  1848
• Pubmed identfication
  • 8626780
  • 9205128
• RefSeq identity
  • NM_001946
  • NM_022652
• Classification
  • MAP kinase phosphatases
• VEGA ID
  OTTHUMG00000169912

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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