DUSP1 Antibody
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Catalog numberF51156-0.4ML
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PricePlease ask
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Size0.4 ml
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CategoryAntibody
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ConcentrationIn 1X PBS, pH 7.4, with 0.09% sodium azide
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FormPurified
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ConjugationUnconjugated
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ClonePolyclonal antibody
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Recognised antigenDUSP1
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Host animalRabbit (Oryctolagus cuniculus)
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ClonalityPolyclonal (rabbit origin)
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Species reactivityHuman (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
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Tested applicationsWB, IF, ELISA
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Recommended dilutionsWestern blot: 1:1000,Immunofluorescence: 1:10-1:50
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NotesTitration of the DUSP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Intented useThis DUSP1 antibodyis to be used only for research purposes and not for diagnostics..
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UniprotP28562
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PurityPurified
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DescriptionThe expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
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ImmunogenA portion of amino acids 46-76 from the human protein was used as the immunogen for this DUSP1 antibody.
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StorageAliquot the DUSP1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
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PropertiesIf you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolDUSP12, DUSP1
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Short nameAnti-DUSP1
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit Ig
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Alternative nameAntibodies to DUSP1
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Alternative techniqueantibodies
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Alternative to gene targetdual specificity phosphatase 1, CL100 and HVH1 and MKP-1 and MKP1 and PTPN10, DUSP1 and IDBG-57812 and ENSG00000120129 and 1843, MAP kinase tyrosine/serine/threonine phosphatase activity, nuclei, Dusp1 and IDBG-155234 and ENSMUSG00000024190 and 19252, BT.85182 and IDBG-628495 and ENSBTAG00000013863 and 539175
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Gene info
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Identity
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Gene
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Long gene namedual specificity phosphatase 12
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2000-01-31
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Atypical dual specificity phosphatases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namedual specificity phosphatase 1
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Synonyms gene
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-03-03
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MAP kinase phosphatases
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
