DNM1L Antibody (DRP1)

• Catalog number
  F53236-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  DNM1L (DRP1)
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:8000
• Notes
  Titration of the DNM1L antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This DNM1L antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  O00429
• Purity
  Antigen affinity
• Description
  Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution. [UniProt]
• Immunogen
  This DNM1L antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 513-547 amino acids from the C-terminal region of human DRP1/DNM1L.
• Storage
  Aliquot the DNM1L antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  DNM1L   DRP1  
• Gene symbol
  DNM1L, UTRN, DENR
• Short name
  Anti-DNM1L (DRP1)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to DNM1L (DRP1)
• Alternative technique
  antibodies
• Alternative to gene target
  dynamin 1-like, DLP1 and DRP1 and DVLP and DYMPLE and EMPF and HDYNIV, DNM1L and IDBG-26348 and ENSG00000087470 and 10059, protein homodimerization activity, Cell surfaces, Dnm1l and IDBG-136828 and ENSMUSG00000022789 and 74006, DNM1L and IDBG-638362 and ENSBTAG00000011395 and 540892

Gene info

• Identity
  HGNC:2973
• Gene
  DNM1L
• Long gene name
  dynamin 1 like
• Synonyms
  • DRP1
  • DVLP
  • HDYNIV
  • DYMPLE
  • VPS1
• GenBank acession
  • AF000430
• Locus
  12p11.21
• Discovery year
  2000-04-12
• Entrez gene record
  10059
• Pubmed identfication
  • 9348079
  • 9731200
• RefSeq identity
  • NM_012062
• VEGA ID
  OTTHUMG00000169451

Gene info

• Identity
  HGNC:12635
• Gene
  UTRN
• Long gene name
  utrophin
• Synonyms gene
  • DMDL
• Synonyms gene name
  • utrophin (homologous to dystrophin)
• Synonyms
  • DRP
  • DRP1
• GenBank acession
  • AK023675
• Locus
  6q24.2
• Discovery year
  1989-06-30
• Entrez gene record
  7402
• Pubmed identfication
  • 1426262
• Classification
  • Zinc fingers ZZ-type
• VEGA ID
  OTTHUMG00000015746

Gene info

• Identity
  HGNC:2769
• Gene
  DENR
• Long gene name
  density regulated re-initiation and release factor
• Synonyms gene name
  • density-regulated protein
• Synonyms
  • DRP
  • DRP1
  • SMAP-3
• GenBank acession
  • AF038554
• Locus
  12q24.31
• Discovery year
  1999-06-17
• Entrez gene record
  8562
• Pubmed identfication
  • 9628587
  • 16982740
  • 20713520
  • 27239039
• RefSeq identity
  • NM_003677
• VEGA ID
  OTTHUMG00000168844

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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