DDR1 Antibody

• Catalog number
  R30978
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  DDR1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the DDR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This DDR1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q08345
• Purity
  Antigen affinity
• Description
  Discoidin domain receptor family, member 1, also known as NEP, EDDR1, NTRK4, TRKE, DDR, CAK or RTK6, is a human gene. The protein encoded by this gene is a DDR that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. The fibrillar collagens and immobilized collagen activated DDR1 receptor phosphorylation after prolonged treatment. Bhatt et al.(2000) showed that the protein was highly expressed in the cerebellum of developing and adult mouse brain, and that both DDR1 and Collagen IV were highly expressed in the pial layer of the cerebellar cortex. Cocultures of Collagen I- and IV-expressing mouse pial cells with DDR1-expressing granule cells resulted in granule cell neurite extension. Inhibition of collagen-DDR1 signaling reduced granule cell neurite elongation.
• Immunogen
  An amino acid sequence from the C-terminus of human DDR1/RKT6 (FSQLHRFLAEDALNTV) was used as the immunogen for this DDR1 antibody.
• Storage
  After reconstitution, the DDR1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  DDR1  
• Gene symbol
  DDR1-DT, DDR1
• Short name
  Anti-DDR1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to DDR1
• Alternative technique
  antibodies
• Alternative to gene target
  discoidin domain receptor tyrosine kinase 1, CAK and CD167 and DDR and EDDR1 and HGK2 and MCK10 and NEP and NTRK4 and PTK3 and PTK3A and RTK6 and TRKE, DDR1 and IDBG-76157 and ENSG00000204580 and 100616237,780, transferase activity, Extracellular, Ddr1 and IDBG-178873 and ENSMUSG00000003534 and 12305, DDR1 and IDBG-634478 and ENSBTAG00000010682 and 534092

Gene info

• Identity
  HGNC:28694
• Gene
  DDR1-DT
• Long gene name
  DDR1 divergent transcript
• Synonyms gene
  • TIGD1L
  • DDR1-AS1
• Synonyms gene name
  • tigger transposable element derived 1-like
  • DDR1 antisense RNA 1 (non-protein coding)
  • DDR1 antisense RNA 1
  • DDR1 antisense RNA 1 (head to head)
• Synonyms
  • bPG70P20.2
  • bCX111D4.7
  • bQB10J12.1
• GenBank acession
  • AL137624
• Locus
  6p21.33
• Discovery year
  2004-06-15
• Entrez gene record
  414771
• Classification
  • Divergent transcripts
• VEGA ID
  OTTHUMG00000031229

Gene info

• Identity
  HGNC:2730
• Gene
  DDR1
• Long gene name
  discoidin domain receptor tyrosine kinase 1
• Synonyms gene
  • NTRK4
  • PTK3A
  • NEP
  • CAK
  • EDDR1
• Synonyms gene name
  • discoidin domain receptor family, member 1
• Synonyms
  • RTK6
  • CD167
• GenBank acession
  • X99031
• Locus
  6p21.33
• Discovery year
  1994-08-29
• Entrez gene record
  780
• Pubmed identfication
  • 7789998
• RefSeq identity
  • NM_013994
• Classification
  • Receptor tyrosine kinases
  • CD molecules
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000031236

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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