Dclk1 Antibody
-
Catalog numberF44334-0.4ML
-
PricePlease ask
-
Size0.4 ml
-
-
CategoryAntibody
-
ConcentrationIn 1X PBS, pH 7.4, with 0.09% sodium azide
-
FormAntigen affinity purified
-
ConjugationUnconjugated
-
ClonePolyclonal antibody
-
Recognised antigenDclk1
-
Host animalRabbit (Oryctolagus cuniculus)
-
ClonalityPolyclonal (rabbit origin)
-
Species reactivityMouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
-
Tested applicationsWB, ELISA
-
Recommended dilutionsWestern blot: 1:1000
-
NotesTitration of the Dclk1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
-
Intented useThis Dclk1 antibodyis to be used only for research purposes and not for diagnostics..
-
UniprotQ9JLM8
-
PurityAntigen affinity
-
DescriptionThis gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been found, but the biological validity of some variants has not been determined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.
-
ImmunogenA portion of amino acids 153-181 from the mouse protein was used as the immunogen for this Dclk1 antibody.
-
StorageAliquot the Dclk1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
-
PropertiesIf you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translationanticorps
-
Gene target
-
Gene symbolDCLK1
-
Short nameAnti-Dclk1
-
TechniqueAntibody, antibodies against human proteins, antibodies for
-
IsotypeRabbit Ig
-
Alternative nameAntibodies to Dclk1
-
Alternative techniqueantibodies
-
Gene info
-
Identity
-
Gene
-
Long gene namedoublecortin like kinase 1
-
Synonyms gene
-
Synonyms gene name
- doublecortin and CaM kinase-like 1
- doublecortin-like kinase 1
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1999-02-22
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Doublecortin superfamily
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data