Cyclin D Antibody (CCND1)
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Catalog number
F47705-0.4ML
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Price
Please ask
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Size
0.4 ml
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Category
Antibody
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Concentration
In 1X PBS, pH 7.4, with 0.09% sodium azide
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Form
Antigen affinity purified
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Conjugation
Unconjugated
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Clone
Polyclonal antibody
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Recognised antigen
Cyclin D (CCND1)
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Host animal
Rabbit (Oryctolagus cuniculus)
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Clonality
Polyclonal (rabbit origin)
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Species reactivity
Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
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Tested applications
WB, ELISA
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Recommended dilutions
Western blot: 1:1000
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Notes
Titration of the CCND1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Intented use
This CCND1 antibodyis to be used only for research purposes and not for diagnostics..
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Uniprot
P24385
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Purity
Antigen affinity
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Description
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
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Immunogen
A portion of amino acids 267-294 from the human protein was used as the immunogen for this CCND1 antibody.
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Storage
Aliquot the CCND1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
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Properties
If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
CCND1
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Short name
Anti-Cyclin D (CCND1)
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Technique
Antibody, antibodies against human proteins, antibodies for
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Isotype
Rabbit Ig
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Alternative name
Antibodies to Cyclin D (CCND1)
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Alternative technique
antibodies
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Alternative to gene target
cyclin D1, BCL1 and D11S287E and PRAD1 and U21B31, CCND1 and IDBG-61868 and ENSG00000110092 and 595, proline-rich region binding, nuclei, Ccnd1 and IDBG-212973 and ENSMUSG00000070348 and 12443, CCND1 and IDBG-645012 and ENSBTAG00000017514 and 524530
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Gene info
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Identity
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Gene
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Long gene name
cyclin D1
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Synonyms gene
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Synonyms gene name
- cyclin D1 (PRAD1: parathyroid adenomatosis 1)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1991-06-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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