Cx43 Antibody Connexin 43

• Catalog number
  R30201
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Cx43 Connexin 43
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P, IHC-F, ICC
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml,IHC (Frozen): 0.5-1ug/ml,Immunocytochemistry: 0.5-1ug/ml
• Notes
  Titration of the Cx43 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This Cx43 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P17302
• Purity
  Antigen affinity
• Description
  Connexin 43 (Cx43), also called GAP Junction Protein, alpha, is a member of the connexin gene family and is abundantly expressed in the heart and liver. Connexin 43, the major protein of gap junctions in the heart, is targeted by several protein kinases that regulate myocardial cell-cell coupling. Cx43 also plays a critical role in the physiology of hearing, presumably by participating in the recycling of potassium to the cochlear endolymph.
• Immunogen
  Amino acids 351-367 (HELQPLAIVDQRPSSRA-human) were used as the immunogen for this Cx43 antibody (100% conserved in mouse and rat).
• Storage
  The lyophilized Cx43 antibody can be stored at 4oC to -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. After reconstitution, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Cx43   Connexin  
• Gene symbol
  GJA1
• Short name
  Anti-Cx43 Connexin 43
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to Cx43 Connexin 43
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:4274
• Gene
  GJA1
• Long gene name
  gap junction protein alpha 1
• Synonyms gene
  • ODDD
  • GJAL
• Synonyms gene name
  • gap junction protein, alpha-like
  • gap junction protein, alpha 1, 43kDa (connexin 43)
  • gap junction protein, alpha 1, 43kDa
• Synonyms
  • CX43
  • ODD
  • ODOD
  • SDTY3
• Synonyms name
  • oculodentodigital dysplasia (syndactyly type III)
  • connexin 43
• GenBank acession
  • BC026329
• Locus
  6q22.31
• Discovery year
  1990-08-03
• Entrez gene record
  2697
• Pubmed identfication
  • 10331943
  • 1646158
• RefSeq identity
  • NM_000165
• Classification
  • Gap junction proteins
• VEGA ID
  OTTHUMG00000015479
• Locus Specific Databases
  • Hereditary Hearing Loss Homepage
  • LRG_1289

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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