Complement Factor I Antibody / CFI

• Catalog number
  R32399
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Complement Factor I / CFI
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.1-0.5ug/ml
• Intented use
  This Factor I antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P05156
• Purity
  Antigen affinity
• Description
  Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene. This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene.
• Immunogen
  Amino acids K19-D220 were used as the immunogen for the Factor I antibody.
• Storage
  After reconstitution, the Factor I antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Additional description
  Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.
• French translation
  anticorps

• Gene target
  Complement   Factor   CFI  
• Gene symbol
  CFI
• Short name
  Anti-Complement Factor I / CFI
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to Complement Factor I / CFI
• Alternative technique
  antibodies
• Alternative to gene target
  complement factor I, AHUS3 and ARMD13 and C3b-INA and C3BINA and FI and IF and KAF, CFI and IDBG-33966 and ENSG00000205403 and 3426, metal ion binding, nuclei, Cfi and IDBG-193652 and ENSMUSG00000058952 and 12630, BT.64790 and IDBG-640204 and ENSBTAG00000034501 and 513197

Gene info

• Identity
  HGNC:5394
• Gene
  CFI
• Long gene name
  complement factor I
• Synonyms gene
  • IF
• Synonyms gene name
  • I factor (complement)
• Synonyms
  • FI
  • C3b-INA
  • KAF
• Synonyms name
  • Konglutinogen-activating factor
  • C3b-inactivator
• GenBank acession
  • J02770
• Locus
  4q25
• Discovery year
  1986-01-01
• Entrez gene record
  3426
• Pubmed identfication
  • 2956252
• RefSeq identity
  • NM_000204
• Classification
  • Complement system regulators and receptors
  • Scavenger receptor cysteine rich domain containing
• VEGA ID
  OTTHUMG00000161109
• Locus Specific Databases
  • CFIbase: Mutation registry for Factor I deficiency (previously known as IFbase)
  • LRG_48

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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