COL1A1 Antibody

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• Catalog number
  F43882-0.4ML
• Price:

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• Size
  0.4 ml

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• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  COL1A1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC, ELISA
• Recommended dilutions
  Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
• Notes
  Titration of the COL1A1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This COL1A1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P02452
• Purity
  Antigen affinity
• Description
  This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish].
• Immunogen
  A portion of amino acids 1077-1106 from the human protein was used as the immunogen for this COL1A1 antibody.
• Storage
  Aliquot the COL1A1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

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• Gene target
  COL1A1  
• Gene symbol
  COL1A1
• Short name
  Anti-COL1A1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to COL1A1
• Alternative technique
  antibodies
• Alternative to gene target
  collagen, type I, alpha 1, OI4, COL1A1 and IDBG-58238 and ENSG00000108821 and 1277, platelet-derived growth factor binding, Extracellular, Col1a1 and IDBG-209263 and ENSMUSG00000001506 and 12842, COL1A1 and IDBG-638637 and ENSBTAG00000013103 and 282187

Gene info

• Identity
  HGNC:2197
• Gene
  COL1A1
• Long gene name
  collagen type I alpha 1 chain
• Synonyms gene name
  • collagen, type I, alpha 1
• Synonyms
  • OI4
• GenBank acession
  • Z74615
• Locus
  17q21.33
• Discovery year
  2001-06-22
• Entrez gene record
  1277
• Pubmed identfication
  • 3178743
  • 2857713
• RefSeq identity
  • NM_000088
• Classification
  • Collagens
• VEGA ID
  OTTHUMG00000148674
• Locus Specific Databases
  • Osteogenesis Imperfecta Variant Database
  • LRG_1

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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