Claudin 1 Antibody (CLDN1) [Loop 2]
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Catalog number
F49579-0.08ML
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Price
Please ask
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Size
0.08 ml
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Category
Antibody
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Concentration
In 1X PBS, pH 7.4, with 0.09% sodium azide
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Form
Purified
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Conjugation
Unconjugated
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Clone
Polyclonal antibody
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Recognised antigen
Claudin 1 (CLDN1) [Loop 2]
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Host animal
Rabbit (Oryctolagus cuniculus)
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Clonality
Polyclonal (rabbit origin)
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Species reactivity
Human (Homo sapiens), Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
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Tested applications
WB, ELISA
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Recommended dilutions
Western blot: 1:1000
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Notes
Titration of the Claudin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Intented use
This Claudin 1 antibodyis to be used only for research purposes and not for diagnostics..
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Uniprot
O95832
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Purity
Purified
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Description
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. CLDN1 acts as a coreceptor for HCV entry into hepatic cells. [UniProt]
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Immunogen
A portion of amino acids 122-163 from the human protein (loop 2) was used as the immunogen for this Claudin 1 antibody.
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Storage
Aliquot the Claudin 1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
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Properties
If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
CLDN1
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Short name
Anti-Claudin 1 (CLDN1) [Loop 2]
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Technique
Antibody, antibodies against human proteins, antibodies for
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Isotype
Rabbit Ig
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Alternative name
Antibodies to Claudin 1 (CLDN1) [Loop 2]
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Alternative technique
antibodies
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Alternative to gene target
claudin 1, CLD1 and ILVASC and SEMP1, CLDN1 and IDBG-69639 and ENSG00000163347 and 9076, identical protein binding, Cell surfaces, Cldn1 and IDBG-150373 and ENSMUSG00000022512 and 12737, CLDN1 and IDBG-634518 and ENSBTAG00000013148 and 414922
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Gene info
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Identity
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Gene
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Long gene name
claudin 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1998-11-19
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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