CFTR Antibody

• Catalog number
  R31324
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  CFTR
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the CFTR antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This CFTR antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P13569
• Purity
  Antigen affinity
• Description
  Cystic fibrosis transmembrane conductance regulator, also called ABC35 or ABCC7, is a protein that in humans is encoded by the CFTR gene. This gene is mapped to 7q31.2. This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens.
• Immunogen
  An amino acid sequence from the C-terminus of human CFTR (QIAALKEETEEEVQDTRL) was used as the immunogen for this CFTR antibody.
• Storage
  After reconstitution, the CFTR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CFTR  
• Gene symbol
  CFTR, CFTR-AS1
• Short name
  Anti-CFTR
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to CFTR
• Alternative technique
  antibodies
• Alternative to gene target
  cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7), ABC35 and ABCC7 and CF and CFTR/MRP and dJ760C5.1 and MRP7 and TNR-CFTR, CFTR and IDBG-37713 and ENSG00000001626 and 1080, ATPase activity, Cell surfaces, Cftr and IDBG-129229 and ENSMUSG00000041301 and 12638, CFTR and IDBG-632747 and ENSBTAG00000006589 and 281067

Gene info

• Identity
  HGNC:1884
• Gene
  CFTR
• Long gene name
  CF transmembrane conductance regulator
• Synonyms gene
  • CF
  • ABCC7
• Synonyms gene name
  • cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)
• Synonyms
  • MRP7
  • ABC35
  • TNR-CFTR
  • dJ760C5.1
  • CFTR/MRP
• Synonyms name
  • ATP-binding cassette sub-family C, member 7
• GenBank acession
  • M28668
• Locus
  7q31.2
• Discovery year
  1986-01-01
• Entrez gene record
  1080
• Pubmed identfication
  • 2772657
• RefSeq identity
  • NM_000492
• Classification
  • ATP binding cassette subfamily C
  • Chloride channels, ATP-gated CFTR
• VEGA ID
  OTTHUMG00000023076
• Locus Specific Databases
  • Cystic Fibrosis
  • LRG_663

Gene info

• Identity
  HGNC:40144
• Gene
  CFTR-AS1
• Long gene name
  CFTR antisense RNA 1
• Synonyms
  • BGas
• GenBank acession
  • BG213071
• Locus
  7q31.2
• Discovery year
  2017-07-26
• Entrez gene record
  111082987
• Pubmed identfication
  • 27434588
• RefSeq identity
  • NR_149084
• Classification
  • Antisense RNAs

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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