CDKN2B Antibody

• Catalog number
  F43554-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  CDKN2B
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the CDKN2B antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This CDKN2B antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P42772
• Purity
  Antigen affinity
• Description
  This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
• Immunogen
  A portion of amino acids 103-131 from the human protein was used as the immunogen for this CDKN2B antibody.
• Storage
  Aliquot the CDKN2B antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CDKN2B  
• Gene symbol
  CDKN2B-AS1, CDKN2B
• Short name
  Anti-CDKN2B
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to CDKN2B
• Alternative technique
  antibodies
• Alternative to gene target
  cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4), CDK4I and INK4B and MTS2 and P15 and p15INK4b and TP15, CDKN2B and IDBG-54658 and ENSG00000147883 and 1030, protein kinase binding, nuclei, Cdkn2b and IDBG-162957 and ENSMUSG00000073802 and 12579, BT.45725 and IDBG-630040 and ENSBTAG00000016412 and 527124

Gene info

• Identity
  HGNC:34341
• Gene
  CDKN2B-AS1
• Long gene name
  CDKN2B antisense RNA 1
• Synonyms gene
  • CDKN2BAS
• Synonyms gene name
  • CDKN2B antisense RNA (non-protein coding)
• Synonyms
  • ANRIL
  • RP11-145E5.4
  • NCRNA00089
  • p15AS
  • CDKN2B-AS
  • PCAT12
• Synonyms name
  • antisense RNA in the INK4 locus
  • non-protein coding RNA 89
  • p15 antisense RNA
  • CDKN2B antisense RNA (non-protein coding)
  • prostate cancer associated transcript 12
• GenBank acession
  • BC038540
• Locus
  9p21.3
• Discovery year
  2008-11-25
• Entrez gene record
  100048912
• Pubmed identfication
  • 18048406
  • 17440112
  • 21532571
  • 23416462
• RefSeq identity
  • NR_003529
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000019689

Gene info

• Identity
  HGNC:1788
• Gene
  CDKN2B
• Long gene name
  cyclin dependent kinase inhibitor 2B
• Synonyms gene name
  • cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
• Synonyms
  • P15
  • MTS2
  • INK4B
  • TP15
  • CDK4I
  • p15INK4b
• GenBank acession
  • AB060808
• Locus
  9p21.3
• Discovery year
  1995-06-14
• Entrez gene record
  1030
• Pubmed identfication
  • 8078588
• RefSeq identity
  • NM_004936
• VEGA ID
  OTTHUMG00000019691

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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