CD1a Antibody

• Catalog number
  V3253-20UG
• Price
  Please ask
• Size
  20 ug

• Category
  Antibody
• Concentration
  0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
• Form
  Purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  CD1a
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens). Other species not known. ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  FACS, IHC, IF
• Recommended dilutions
  FACS: 0.5-1ug/million cells,IF: 1-2ug/ml,IHC (FFPE): 0.5-1ug/ml for 30 min at RT
• Notes
  The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CD1a antibody to be titered up or down for optimal performance.
• Intented use
  This CD1a antibodyis to be used only for research purposes and not for diagnostics..
• Gene ID
  909
• Uniprot
  P06126
• Purity
  Purified by protein A Affinity Chromatography
• Description
  At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).
• Immunogen
  Human CD1a protein was used as the immunogen for this CD1a antibody.
• Storage
  Store the CD1a antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
• Localization
  Cell surface, cytoplasmic
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CD1a  
• Gene symbol
  CD1A
• Short name
  Anti-CD1a
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to CD1a
• Alternative technique
  antibodies
• Alternative to gene target
  CD1a molecule, CD1 and FCB6 and HTA1 and R4 and T6, CD1A and IDBG-103736 and ENSG00000158477 and 909, protein binding, Plasma membranes

Gene info

• Identity
  HGNC:1634
• Gene
  CD1A
• Long gene name
  CD1a molecule
• Synonyms gene
  • CD1
• Synonyms gene name
  • CD1A antigen, a polypeptide
  • CD1a antigen
• GenBank acession
  • M28825
• Locus
  1q23.1
• Discovery year
  1988-05-11
• Entrez gene record
  909
• Pubmed identfication
  • 2447586
  • 2784820
• RefSeq identity
  • NM_001763
• Classification
  • C1-set domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000017512

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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