CCND1 Antibody

• Catalog number
  F40062-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  CCND1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the CCND1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This CCND1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q6FI00
• Purity
  Purified
• Description
  CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of the gene encoding this protein, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
• Immunogen
  A portion of amino acids 1-30 from the human protein was used as the immunogen for this CCND1 antibody.
• Storage
  Aliquot the CCND1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CCND1  
• Gene symbol
  CCND1
• Short name
  Anti-CCND1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to CCND1
• Alternative technique
  antibodies
• Alternative to gene target
  cyclin D1, BCL1 and D11S287E and PRAD1 and U21B31, CCND1 and IDBG-61868 and ENSG00000110092 and 595, proline-rich region binding, nuclei, Ccnd1 and IDBG-212973 and ENSMUSG00000070348 and 12443, CCND1 and IDBG-645012 and ENSBTAG00000017514 and 524530

Gene info

• Identity
  HGNC:1582
• Gene
  CCND1
• Long gene name
  cyclin D1
• Synonyms gene
  • BCL1
  • D11S287E
  • PRAD1
• Synonyms gene name
  • cyclin D1 (PRAD1: parathyroid adenomatosis 1)
• Synonyms
  • U21B31
• Synonyms name
  • parathyroid adenomatosis 1
  • B-cell CLL/lymphoma 1
  • G1/S-specific cyclin D1
• GenBank acession
  • Z23022
• Locus
  11q13.3
• Discovery year
  1991-06-06
• Entrez gene record
  595
• Pubmed identfication
  • 1826542
  • 1833066
• RefSeq identity
  • NM_053056
• Classification
  • Cyclins
• VEGA ID
  OTTHUMG00000167877
• Locus Specific Databases
  • LRG_990

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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