Caspase-12 Antibody

• Catalog number
  F41865-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Caspase-12
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC, FACS, IF, ELISA
• Recommended dilutions
  Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Flow Cytometry: 1:10-1:50,Immunofluorescence: 1:10-1:50
• Notes
  Titration of the Caspase-12 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This Caspase-12 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q6UXS9
• Purity
  Antigen affinity
• Description
  Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
• Immunogen
  A portion of amino acids 165-193 from the human protein was used as the immunogen for this Caspase-12 antibody.
• Storage
  Aliquot the Caspase-12 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Additional description
  Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
• French translation
  anticorps

• Gene target
  Caspase-12  
• Gene symbol
  CASP12, AVEN, NLRC4
• Short name
  Anti-Caspase-12
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to Caspase-12
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:19004
• Gene
  CASP12
• Long gene name
  caspase 12 (gene/pseudogene)
• Synonyms gene
  • CASP12P1
• Synonyms gene name
  • caspase 12 pseudogene 1
  • caspase 12
• GenBank acession
  • AF464191
• Locus
  11q22.3
• Discovery year
  2002-07-25
• Entrez gene record
  100506742
• Pubmed identfication
  • 12054529
  • 9038361
  • 16917906
  • 16532395
• RefSeq identity
  • NM_001191016
• Classification
  • Caspases
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000154965

Gene info

• Identity
  HGNC:13509
• Gene
  AVEN
• Long gene name
  apoptosis and caspase activation inhibitor
• Synonyms
  • PDCD12
• Synonyms name
  • cell death regulator aven
  • programmed cell death 12
• GenBank acession
  • AF283508
• Locus
  15q14
• Discovery year
  2002-09-17
• Entrez gene record
  57099
• Pubmed identfication
  • 10949025
• RefSeq identity
  • NM_020371
• VEGA ID
  OTTHUMG00000129371

Gene info

• Identity
  HGNC:16412
• Gene
  NLRC4
• Long gene name
  NLR family CARD domain containing 4
• Synonyms gene
  • CARD12
• Synonyms gene name
  • caspase recruitment domain family, member 12
• Synonyms
  • CLAN1
  • ipaf
  • CLANA
  • CLANB
  • CLANC
  • CLAND
  • CLR2.1
  • CLAN
• Synonyms name
  • nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
  • NOD-like receptor C4
• GenBank acession
  • AF376061
• Locus
  2p22.3
• Discovery year
  2002-09-19
• Entrez gene record
  58484
• Pubmed identfication
  • 11374873
• RefSeq identity
  • NM_021209
• Classification
  • NLR family
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000152107
• Locus Specific Databases
  • LRG_1317

MeSH Data

• Name
  Models, Chemical
• Concept
  Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
• Tree numbers
  • E05.599.495

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