BMPR1A Antibody

• Catalog number
  F47724-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  BMPR1A
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IF, IHC, ELISA
• Recommended dilutions
  Western blot: 1:1000,Immunofluorescence: 1:10-1:50,IHC (Paraffin): 1:50-1:100
• Notes
  Titration of the BMPR1A antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This BMPR1A antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P36894
• Purity
  Purified
• Description
  The bone morphogenetic protein (BMP) receptors belong to a family of transmembrane serine/threonine kinases including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. Both activins and TGF-beta transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMP receptors are highly expressed in bone, skeletal muscle, heart and liver tissue. BMPRs play a crucial role during development as mutations or deletions to the BMPR genes can cause juvenile polyposis, disrupt normal dorsal/ventral patterning during limb development, and may be a factor in the progession of Cowden-like syndrome. Germline mutations in the BMPR2 gene encoding bone morphogenetic protein (BMP) type II receptor (BMPR-II) have been reported in patients with primary pulmonary hypertension (PPH).
• Immunogen
  A portion of amino acids 21-51 from the human protein was used as the immunogen for this BMPR1A antibody.
• Storage
  Aliquot the BMPR1A antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  BMPR1A  
• Gene symbol
  BMPR1A
• Short name
  Anti-BMPR1A
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to BMPR1A
• Alternative technique
  antibodies
• Alternative to gene target
  bone morphogenetic protein receptor, type IA, 10q23del and ACVRLK3 and ALK3 and CD292 and SKR5, BMPR1A and IDBG-81081 and ENSG00000107779 and 657, transferase activity, Cell surfaces, Bmpr1a and IDBG-149689 and ENSMUSG00000021796 and 12166, BT.48514 and IDBG-631434 and ENSBTAG00000000231 and 404101

Gene info

• Identity
  HGNC:1076
• Gene
  BMPR1A
• Long gene name
  bone morphogenetic protein receptor type 1A
• Synonyms gene
  • ACVRLK3
• Synonyms gene name
  • bone morphogenetic protein receptor, type IA
• Synonyms
  • ALK3
  • CD292
• GenBank acession
  • BC028383
• Locus
  10q23.2
• Discovery year
  1994-12-12
• Entrez gene record
  657
• Pubmed identfication
  • 8397373
  • 9730621
• RefSeq identity
  • NM_004329
• Classification
  • Type 1 receptor serine/threonine kinases
  • CD molecules
• VEGA ID
  OTTHUMG00000018657
• Locus Specific Databases
  • LRG_298

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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