Beta Arrestin 1 Antibody

• Catalog number
  R31275
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Beta Arrestin 1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the beta Arrestin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This beta Arrestin 1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P49407
• Purity
  Antigen affinity
• Description
  Beta Arrestin 1 is a protein which in humans is encoded by the ARRB1 gene. Members of arrestin/beta-arrestin protein family are though to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. By fluorescence in situ hybridization,this gene is mapped to 11q13.4. Beta Arrestin 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions.
• Immunogen
  An amino acid sequence from the N-terminus of human ARRB1 (ANVQSFPPAPEDKKPLTRLQER) was used as the immunogen for this beta Arrestin 1 antibody (100% homologous in human, mouse and rat).
• Storage
  After reconstitution, the beta Arrestin 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Beta   Arrestin  
• Gene symbol
  ARRB1
• Short name
  Anti-Beta Arrestin 1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to Beta Arrestin 1
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:711
• Gene
  ARRB1
• Long gene name
  arrestin beta 1
• Synonyms gene
  • ARR1
• Synonyms gene name
  • arrestin, beta 1
• Synonyms name
  • arrestin 2
• GenBank acession
  • BC003636
• Locus
  11q13.4
• Discovery year
  1994-01-10
• Entrez gene record
  408
• Pubmed identfication
  • 8486659
• RefSeq identity
  • NM_004041
• Classification
  • Classical arrestins
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000165444

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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