ApoE Antibody (Apolipoprotein E)

• Catalog number
  F50536-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  ApoE (Apolipoprotein E)
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  IHC, WB, ELISA
• Recommended dilutions
  Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
• Notes
  Titration of the ApoE antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This ApoE antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P02649
• Purity
  Antigen affinity
• Description
  Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III),in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
• Immunogen
  A portion of amino acids 263-292 from the human protein was used as the immunogen for this ApoE antibody.
• Storage
  Aliquot the ApoE antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ApoE   Apolipoprotein  
• Gene symbol
  APOE
• Short name
  Anti-ApoE (Apolipoprotein E)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to ApoE (Apolipoprotein E)
• Alternative technique
  antibodies
• Alternative to gene target
  apolipoprotein E, AD2 and LDLCQ5 and LPG, APOE and IDBG-56807 and ENSG00000130203 and 348, lipoprotein particle binding, nuclei, Apoe and IDBG-152108 and ENSMUSG00000002985 and 11816, APOE and IDBG-639311 and ENSBTAG00000010123 and 281004

Gene info

• Identity
  HGNC:613
• Gene
  APOE
• Long gene name
  apolipoprotein E
• Synonyms gene
  • AD2
• Synonyms gene name
  • Alzheimer disease 2 (APOE*E4-associated, late onset)
• GenBank acession
  • K00396
• Locus
  19q13.32
• Discovery year
  2001-06-22
• Entrez gene record
  348
• Pubmed identfication
  • 10662539
• RefSeq identity
  • NM_000041
• Classification
  • Apolipoproteins
• VEGA ID
  OTTHUMG00000128901
• Locus Specific Databases
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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