AIRE Antibody

• Catalog number
  R32465
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  AIRE
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.5-1ug/ml
• Added buffer
  Lyophilized from 1X Phosphate Buffered Saline (PBS) with 2.5% BSA and 0.025% sodium azide
• Intented use
  This AIRE antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  O43918
• Purity
  Antigen affinity
• Description
  The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).
• Immunogen
  Amino acids M1-K120 from the human protein were used as the immunogen for the AIRE antibody.
• Storage
  Prior to reconstitution, store at 4oC. After reconstitution, the AIRE antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  AIRE  
• Gene symbol
  AIRE
• Short name
  Anti- AIRE
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to AIRE
• Alternative technique
  antibodies
• Alternative to gene target
  autoimmune regulator, AIRE1 and APECED and APS1 and APSI and PGA1, AIRE and IDBG-5152 and ENSG00000160224 and 326, translation regulator activity, nuclei, Aire and IDBG-168233 and ENSMUSG00000000731 and 11634, AIRE and IDBG-639674 and ENSBTAG00000023393 and

Gene info

• Identity
  HGNC:360
• Gene
  AIRE
• Long gene name
  autoimmune regulator
• Synonyms gene
  • APECED
• Synonyms gene name
  • autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
• Synonyms
  • PGA1
  • APS1
• Synonyms name
  • autoimmune polyendocrinopathy candidiasis ectodermal dystrophy
• GenBank acession
  • AB006684
• Locus
  21q22.3
• Discovery year
  1997-09-05
• Entrez gene record
  326
• Pubmed identfication
  • 9398840
• Classification
  • PHD finger proteins
• VEGA ID
  OTTHUMG00000086921
• Locus Specific Databases
  • AIREbase: Mutation registry for APECED
  • LRG_18

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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