ACK1 Antibody / Activated CDC42 kinase 1

• Catalog number
  F50698-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  ACK1 / Activated CDC42 kinase 1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC, ELISA
• Recommended dilutions
  Western blot: 1:500-1000,IHC (Paraffin): 1:50-1:100
• Intented use
  This ACK1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q07912
• Purity
  Purified
• Description
  Activated CDC42 kinase 1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.
• Immunogen
  A portion of amino acids 934-964 from the human protein was used as the immunogen for this ACK1 antibody.
• Storage
  Aliquot the ACK1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Localization
  Cytoplasmic
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ACK1   Activated   CDC42   kinase  
• Gene symbol
  CDC42-AS1, CDC42-IT1, CDC42, TNK2
• Short name
  Anti- ACK1 / Activated CDC42 kinase 1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to ACK1 / Activated CDC42 kinase 1
• Alternative technique
  antibodies
• Alternative to gene target
  cell division cycle 42 (GTP binding protein, 25kDa), CDC42Hs and G25K, CDC42 and IDBG-93614 and ENSG00000070831 and 998, identical protein binding, Cell surfaces, Cdc42 and IDBG-198471 and ENSMUSG00000006699 and 12540, BT.56113 and IDBG-645532 and ENSBTAG00000001700 and 532712

Gene info

• Identity
  HGNC:54314
• Gene
  CDC42-AS1
• Long gene name
  CDC42 antisense RNA 1
• Locus
  1p36.12
• Discovery year
  2019-05-03
• Entrez gene record
  112268223
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:41317
• Gene
  CDC42-IT1
• Long gene name
  CDC42 intronic transcript 1
• Synonyms gene name
  • CDC42 intronic transcript 1 (non-protein coding)
• Locus
  1p36.12
• Discovery year
  2011-05-19
• Classification
  • Intronic transcripts
• VEGA ID
  OTTHUMG00000002890

Gene info

• Identity
  HGNC:1736
• Gene
  CDC42
• Long gene name
  cell division cycle 42
• Synonyms gene name
  • cell division cycle 42 (GTP-binding protein, 25kD)
  • cell division cycle 42 (GTP binding protein, 25kDa)
• Synonyms
  • G25K
  • CDC42Hs
• Synonyms name
  • GTP binding protein, 25kDa
• GenBank acession
  • BC018266
• Locus
  1p36.12
• Discovery year
  1991-06-06
• Entrez gene record
  998
• Pubmed identfication
  • 2124704
  • 2122236
• RefSeq identity
  • NM_001791
• Classification
  • Rho family GTPases
• VEGA ID
  OTTHUMG00000002753
• Locus Specific Databases
  • LRG_1326

Gene info

• Identity
  HGNC:19297
• Gene
  TNK2
• Long gene name
  tyrosine kinase non receptor 2
• Synonyms gene name
  • tyrosine kinase, non-receptor, 2
• Synonyms
  • p21cdc42Hs
  • ACK
  • ACK1
• Synonyms name
  • activated Cdc42-associated kinase 1
• GenBank acession
  • L13738
• Locus
  3q29
• Discovery year
  2005-01-19
• Entrez gene record
  10188
• Pubmed identfication
  • 8497321
  • 14506255
• RefSeq identity
  • NM_005781
• Classification
  • MicroRNA protein coding host genes
  • TNK family tyrosine kinases
• VEGA ID
  OTTHUMG00000155737

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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