Wilm's Tumor 1 (WT1) (Wilm's Tumor & Mesothelial Marker) Mouse Monoclonal Antibody
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Products_type
Antibody
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Products_short_name
[Wilm's Tumor 1 (WT1)]
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Products_name_syn
[WT1; AWT1; FWT1; GUD; NPHS4; WAGR; Wilms tumor 1]
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Other_names
[Wilms tumor protein isoform A; Wilms tumor protein; Wilms tumor protein; Wilms tumor 1; WT33]
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Products_gene_name
[WT1]
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Other_gene_names
[WT1; WT1; GUD; AWT1; WAGR; WT33; NPHS4; WIT-2; EWS-WT1]
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Clonality
Monoclonal
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Clone
[WT1/857]
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Reactivity
Human and Rat. Weakly reacts with Mouse. Others-not known
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Specificity
Recognizes a 47-55kDa-tumor suppressor protein, identified as Wilm's Tumor (WT1) protein. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilm’s tumors. WT1, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous. Wilm’s tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm’s tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody. WT1 protein expression in mesothelial cells has become a reliable marker for the mesotheliomas.
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Form
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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Storage_stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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Tested_application
Immunohistology (Formalin-fixed)
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Properties
If you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
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French translation
anticorps
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Gene target
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Gene symbol
WT1-AS, WT1
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Short name
Wilm's Tumor 1 (WT1) (Wilm's Tumor & Mesothelial ) Mouse Monoclonal Antibody
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Technique
Mouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Component cell markers and DNA bp. markers are genetic markers er genes or DNA sequences with a known location on a chromosome that can be used to identify individuals or species. Protein markers in kDA. Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
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Host
Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
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Isotype
IgG1, kappa
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Species
Mouse, Mouses
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Alternative name
Wilm's Tumor 1 (Wilms tumor 1) (Wilm's Tumor & Mesothelial detection labelled) Mouse monoclonal (antibody to-)
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Alternative technique
antibodies, murine
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Alternative to gene target
Wilms tumor 1, AWT1 and EWS-WT1 and GUD and NPHS4 and WAGR and WIT-2 and WT33, WT1 and IDBG-37982 and ENSG00000184937 and 7490, C2H2 zinc finger domain binding, nuclei, Wt1 and IDBG-194872 and ENSMUSG00000016458 and 22431, WT1 and IDBG-636230 and ENSBTAG00000047268 and 782183
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Tissue
tumor
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Gene info
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Identity
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Gene
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Long gene name
WT1 antisense RNA
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Synonyms gene
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Synonyms gene name
- Wilms tumor upstream neighbor 1
- WT1 antisense RNA (non-protein coding)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2005-10-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
WT1 transcription factor
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Synonyms gene
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Synonyms gene name
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Synonyms
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Locus
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Discovery year
1989-04-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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