TIMP-3 (Tissue Inhibitor of Metalloproteinase-3) Rabbit Polyclonal Antibody
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Catalog numberMBS438029
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PricePlease ask
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Size5x0.1 mg (With BSA & Azide at 0.2mg/mL)
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Products_typeAntibody
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Products_short_name[TIMP-3 (Tissue Inhibitor of Metalloproteinase-3)]
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Products_name_syn[HSMRK222, K222TA2, Protein MIG-5, SFD, Sorsby fundus dystrophy pseudo-inflammatory, TIMP metallopeptidase inhibitor 3, Tissue Inhibitor of Metalloproteinase 3]
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Other_names[metalloproteinase inhibitor 3; Metalloproteinase inhibitor 3; metalloproteinase inhibitor 3; TIMP metallopeptidase inhibitor 3; Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3]
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Products_gene_name[TIMP3]
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Other_gene_names[TIMP3; TIMP3; SFD; K222; K222TA2; HSMRK222; TIMP-3]
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ClonalityPolyclonal
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ReactivityHuman, Mouse, Rat, Horse, Cow, Dog
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SpecificityTIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM). An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMPs inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes.
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Form200ug/ml of Ab purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
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Storage_stabilityAntibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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Tested_applicationFlow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
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PropertiesIf you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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DescriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme. 6
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GroupPolyclonals and antibodies
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AboutPolyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera. Rabbits are used for polyclonal antibody production by MyBioSource. Rabbit antibodies are very stable and can be stored for several days at room temperature. MyBioSource adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin nameOryctolagus cuniculus
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French translationanticorps
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Gene target
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Gene symbolTIMP3, TIMP1, MIR1302-3, MIR509-3, MIR7-3, PIRC14, PIRC12, MIR9-3
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Short nameTIMP-3 (Tissue Inhibitor of Metalloproteinase-3) Rabbit Polyclonal Antibody
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TechniquePolyclonal, Antibody, Rabbit, tissue, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope. tissues
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HostRabbit, Rabbits
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IsotypeIgG
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Alternative nameTIMP-3 (Tissue suppressor on Metalloproteinase-3) production species: rabbit polyclonal (antibody to-)
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Alternative techniquepolyclonals, antibodies, tissues, rabbit-anti
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Tissuetissue
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Gene info
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Identity
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Gene
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Long gene nameTIMP metallopeptidase inhibitor 3
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Synonyms gene
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Synonyms gene name
- tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)
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Locus
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Discovery year1993-04-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Tissue inhibitor of metallopeptidases
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameTIMP metallopeptidase inhibitor 1
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Synonyms gene
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Synonyms gene name
- tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)
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Synonyms
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Locus
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Discovery year1986-01-01
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Entrez gene record
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RefSeq identity
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Classification
- Tissue inhibitor of metallopeptidases
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemicroRNA 1302-3
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Synonyms gene
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Synonyms
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Locus
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Discovery year2008-11-03
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR1302 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 509-3
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Synonyms gene
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Synonyms
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Locus
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Discovery year2007-10-24
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR506 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 7-3
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Synonyms gene
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Synonyms
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Locus
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Discovery year2004-04-23
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR7 family
Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 14
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 12
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
Gene info
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Identity
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Gene
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Long gene namemicroRNA 9-3
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Synonyms gene
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Synonyms
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Locus
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Discovery year2004-04-23
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR9 family
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data