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Products_type
Antibody
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Products_short_name
[Thyroid Hormone Receptor, alpha1]
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Products_name_syn
[Anti -Thyroid Hormone Receptor, alpha1 (THRa1)]
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Other_names
[thyroid hormone receptor alpha isoform 1; THRA protein; thyroid hormone receptor alpha; EAR-7; c-erbA-alpha; ERBA-related 7; OTTHUMP00000164469; OTTHUMP00000164470; V-erbA-related protein 7; triiodothyronine receptor; nuclear receptor subfamily 1 group A member 1; thyroid normone nuclear receptor alpha variant 1; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid hormone receptor, alpha]
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Other_gene_names
[THRA; THRA; AR7; EAR7; ERBA; ERBA1; NR1A1; THRA1; THRA2; ERB-T-1; MGC43240; c-ERBA-1; MGC000261; NR1A1]
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Clonality
Polyclonal
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Reactivity
Human
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Specificity
Recognizes Human Thyroid Hormone Receptor alpha. Expected to cross-react with bovine, canine, elephant, equine, gibbon, gorilla, hamster, monkey, mouse, panda, porcine, rabbit, rat and sheep
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Purity
Affinity Purified Purified by immunoaffinity chromatography.
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Form
Supplied as a liquid in PBS, 0.1% sodium azide.
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Storage_stability
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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Tested_application
Immunohistochemistry (IHC)
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Description
Hormone releasing factors and releasing hormones are signaling molecules produced by glands in multicellular organisms. The glands that secrete Luteinizing hormones LHRG and LH, FSH comprise the endocrine signaling system. The term growth hormone releasing hormone GHRH is sometimes extended to include chemicals produced by cells that affect the same cell (autocrine or intracrine signaling) or nearby cells (paracrine signaling). Human recombinant LHRG and GHRH are produced in E. coli or in yeast cells. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
