Thymidylate Synthase (5-FU Resistance Marker) Mouse Monoclonal Antibody

• Catalog number
  MBS438428
• Price
  Please ask
• Size
  5x0.1 mg (Without BSA & Azide at 1mg/mL)

• Products_type
  Antibody
• Products_short_name
  [Thymidylate Synthase]
• Products_name_syn
  [dTMP synthase, TMS, TS, TSase, TYMS protein, Tyms thymidylate synthetase]
• Other_names
  [thymidylate synthase; Thymidylate synthase; thymidylate synthase; thymidylate synthetase]
• Products_gene_name
  [TYMS]
• Other_gene_names
  [TYMS; TYMS; TS; TMS; HST422; TS; TS; TSase]
• Clonality
  Monoclonal
• Clone
  [TS106]
• Reactivity
  Human
• Specificity
  It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
• Form
  200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
• Storage_stability
  Antibody with azide - store at 2 to 8 degree C. Antibody is stable for 24 months.,Non-hazardous. No MSDS required.
• Tested_application
  Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
• Properties
  If you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• French translation
  anticorps

• Gene target
  Thymidylate   Synthase   5-FU   Resistance   Monoclonal  
• Gene symbol
  STK36, MIR1302-5, PIRC22, PIRC23, PIRC20, PIRC21, HTR6, IGKV3OR2-5, IGHV2OR16-5, SNORD116-5
• Short name
  Thymidylate Synthase (5-FU Resistance ) Mouse Monoclonal Antibody
• Technique
  Mouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Component cell markers and DNA bp. markers are genetic markers er genes or DNA sequences with a known location on a chromosome that can be used to identify individuals or species. Protein markers in kDA. Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
• Host
  Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
• Isotype
  IgG1, kappa
• Species
  Mouse, Mouses
• Alternative name
  Thymidylate Synthase (5-FU Resistance detection labelled) Mouse monoclonal (antibody to-)
• Alternative technique
  antibodies, murine

Gene info

• Identity
  HGNC:17209
• Gene
  STK36
• Long gene name
  serine/threonine kinase 36
• Synonyms gene name
  • serine/threonine kinase 36 (fused homolog, Drosophila)
• Synonyms
  • KIAA1278
  • FU
• Synonyms name
  • fused homolog (Drosophila)
• GenBank acession
  • AB033104
• Locus
  2q35
• Discovery year
  2001-11-22
• Entrez gene record
  27148
• Pubmed identfication
  • 10806483
• Classification
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000133079

Gene info

• Identity
  HGNC:35297
• Gene
  MIR1302-5
• Long gene name
  microRNA 1302-5
• Synonyms gene
  • MIRN1302-5
• Synonyms
  • hsa-mir-1302-5
• Locus
  20q13.13
• Discovery year
  2008-11-03
• Entrez gene record
  100302146
• RefSeq identity
  • NR_031634
• Classification
  • MicroRNA MIR1302 family

Gene info

• Identity
  HGNC:37526
• Gene
  PIRC22
• Long gene name
  piwi-interacting RNA cluster 22
• Locus
  5
• Discovery year
  2009-11-05
• Entrez gene record
  100313850
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37527
• Gene
  PIRC23
• Long gene name
  piwi-interacting RNA cluster 23
• Locus
  5
• Discovery year
  2009-11-05
• Entrez gene record
  100313786
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37524
• Gene
  PIRC20
• Long gene name
  piwi-interacting RNA cluster 20
• Locus
  5
• Discovery year
  2009-11-05
• Entrez gene record
  100313785
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37525
• Gene
  PIRC21
• Long gene name
  piwi-interacting RNA cluster 21
• Locus
  5
• Discovery year
  2009-11-05
• Entrez gene record
  100313916
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:5301
• Gene
  HTR6
• Long gene name
  5-hydroxytryptamine receptor 6
• Synonyms gene name
  • 5-hydroxytryptamine (serotonin) receptor 6
  • 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
• Synonyms
  • 5-HT6
  • 5-HT6R
• GenBank acession
  • L41147
• Locus
  1p36.13
• Discovery year
  1997-12-11
• Entrez gene record
  3362
• Pubmed identfication
  • 8522988
• RefSeq identity
  • NM_000871
• Classification
  • 5-hydroxytryptamine receptors, G protein-coupled
• VEGA ID
  OTTHUMG00000002713

Gene info

• Identity
  HGNC:5832
• Gene
  IGKV3OR2-5
• Long gene name
  immunoglobulin kappa variable 3/OR2-5 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 3/OR2-5
  • immunoglobulin kappa variable 3/OR2-5 pseudogene
• Synonyms
  • IGKV3/OR2-5
• GenBank acession
  • X51882
• Locus
  2q11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28854
• Classification
  • Immunoglobulin kappa (IGK) orphons
• VEGA ID
  OTTHUMG00000184519

Gene info

• Identity
  HGNC:5579
• Gene
  IGHV2OR16-5
• Long gene name
  immunoglobulin heavy variable 2/OR16-5 (non-functional)
• Synonyms gene name
  • immunoglobulin heavy variable 2/OR16-5
• Synonyms
  • IGHV2/OR16-5
• GenBank acession
  • L25544
• Locus
  16p11.2
• Discovery year
  2000-04-17
• Entrez gene record
  100129631
• Classification
  • Immunoglobulin heavy (IGH) orphons
• VEGA ID
  OTTHUMG00000152881

Gene info

• Identity
  HGNC:33071
• Gene
  SNORD116-5
• Long gene name
  small nucleolar RNA, C/D box 116-5
• Synonyms
  • HBII-85-5
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033417
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003320
• Classification
  • Small nucleolar RNAs, C/D box

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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