TBLR1 (TBL1XR1, IRA1, C21, DC42, TBL1-related protein 1, transducin (beta)-like 1 X-linked receptor 1)
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Catalog number
MBS610091
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Price
Please ask
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Size
5x0.1 mg
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Products_type
Antibody
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Products_short_name
[TBLR1]
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Products_name_syn
[Anti -TBLR1 (TBL1XR1, IRA1, C21, DC42, TBL1-related protein 1, transducin (beta)-like 1 X-linked receptor 1)]
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Other_names
[Transducin (beta)-like 1 X-linked receptor 1; F-box-like/WD repeat-containing protein TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1; OTTHUMP00000211531; OTTHUMP00000211535; TBL1-related protein 1; transducin beta-like 1X-related protein 1; nuclear receptor co-repressor/HDAC3 complex subunit; nuclear receptor corepressor/HDAC3 complex subunit TBLR1; transducin (beta)-like 1 X-linked receptor 1; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; Transducin beta-like 1X-related protein 1]
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Other_gene_names
[TBL1XR1; TBL1XR1; C21; DC42; IRA1; TBLR1; FLJ12894; IRA1; TBLR1]
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Clonality
Polyclonal
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Reactivity
Human, Mouse, Rat
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Specificity
Chromatin organization plays a fundamental role in regulating transcription in eukaryotic cells. The nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid homone receptors (SMRT) play a role in diverse transcriptional repression pathways. N-CoR and SMRT each exist in large protein complexes, and are thought to mediate repression, at least in part, by their ability to recruit histone deacetylases to generate repressive chromatin. HDAC3 is the main HDAC that associates with N-CoR and SMRT complexes, and its presence is thought to be essential for repression. TBLR1 is a WD-40 repeat protein that also associates with N-CoR and SMRT complexes. Although TBLR1 is thought to be a core component of both the N-CoR and SMRT complexes, its role in these complexes remains to be elucidated.
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Purity
Purified Purified
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Form
Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
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Storage_stability
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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Tested_application
Western Blot (WB)
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Description
The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Gene target
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Gene symbol
TBL1XR1, TBL1Y, TBL1X, TBL1XR1-AS1, PSMG1
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Short name
TBLR1 (TBL1XR1, IRA1, C21, DC42, TBL1- protein 1, transducin (beta)-like 1 X-linked receptor 1)
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Host
Rabbit
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Isotype
IgG
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Alternative name
TBLR1 (TBL1XR1, IRA1, C21, DC42, TBL1-related protein 1, transducin (b)-like 1 X-linked receptor 1)
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Gene info
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Identity
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Gene
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Long gene name
TBL1X receptor 1
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Synonyms gene name
- transducin (beta)-like 1X-linked receptor 1
- transducin beta like 1 X-linked receptor 1
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Synonyms
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GenBank acession
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Locus
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Discovery year
2004-08-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- WD repeat domain containing
- NCoR/SMRT transcriptional repression complex subunits
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VEGA ID
Gene info
Gene info
Gene info
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Identity
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Gene
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Long gene name
TBL1XR1 antisense RNA 1
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Synonyms gene name
- TBL1XR1 antisense RNA 1 (non-protein coding)
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Locus
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Discovery year
2011-07-25
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Classification
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VEGA ID
Gene info
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