STAP1, NT (F56) (BRDG1, Signal-transducing Adaptor Protein 1, Stem Cell Adaptor Protein 1, BCR Downstream-signaling Protein 1, Docking Protein BRDG1)

• Catalog number
  MBS623452
• Price
  Please ask
• Size
  0.2 mL

• Products_type
  Antibody
• Products_short_name
  [STAP1]
• Products_name_syn
  [Anti -STAP1, NT (F56) (BRDG1, Signal-transducing Adaptor Protein 1, Stem Cell Adaptor Protein 1, BCR Downstream-signaling Protein 1, Docking Protein BRDG1)]
• Other_names
  [signal-transducing adaptor protein 1; Signal-transducing adaptor protein 1; signal-transducing adaptor protein 1; OTTHUMP00000159639; OTTHUMP00000159640; docking protein BRDG1; BCR downstream signaling 1; stem cell adaptor protein 1; BCR downstream-signaling protein 1; signal-transducing adaptor protein-1; signal transducing adaptor family member 1; BCR downstream-signaling protein 1; Docking protein BRDG1; Stem cell adaptor protein 1]
• Other_gene_names
  [STAP1; STAP1; BRDG1; STAP-1; BRDG1]
• Clonality
  Polyclonal
• Reactivity
  Human
• Specificity
  Recognizes human STAP1.
• Purity
  Affinity Purified Purified by Protein A affinity chromatography.
• Form
  Supplied as a liquid in PBS, 0.09% sodium azide.
• Storage_stability
  May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Tested_application
  ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Description
  For cells, cell lines and tissues in culture till half confluency. Cell nucleus signaling proteins and molecules are part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as normal tissue homeostasis. Errors in cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated effectively and, theoretically, artificial tissues may be created.
• Test
  Stem cell factors and stem cell growth factors will produce stem cells or be part of a transdifferentiation process to produce other cells. A cell can transdifferentiate by going back to the naive stem cell stadium or directly into the other cell, helped by the stem cell and transdifferentiationf actors. Stem cell growth factors or stem cell factors are mostly used to produce iPSCs or induced pluripotent stem cells by Jamaka or Thomson factors by using for example 5 Lenti-III-CMV viruses, expressing the Yamanaka iPSC factor set (Oct4, Sox2, Nanog and Lin28) + GFP positive control. Trans differentiation will omit the stem cell stadium but stem cell factors sill play an important role in trans differentiation strategies.

• Gene target
  STAP1   F56   BRDG1   Signal-transducing   Adaptor   Protein   Stem   Adaptor   Protein   BCR   Downstream-signaling   Protein   Docking   Protein   BRDG1  
• Gene symbol
  STAP1, BCRP1, UXT, BCRP2, BCRP4, BCR
• Short name
  STAP1, NT (F56) (BRDG1, Signal-transducing Adaptor Protein 1, Stem Adaptor Protein 1, BCR Downstream-signaling Protein 1, Docking Protein BRDG1)
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  STAP1, NT (F56) (BRDG1, Signal-transducing Adaptor Protein 1, progenitor cellular Adaptor Protein 1, BCR Downstream-signaling Protein 1, Docking Protein BRDG1)
• Tissue
  cell, stem

Gene info

• Identity
  HGNC:24133
• Gene
  STAP1
• Long gene name
  signal transducing adaptor family member 1
• Synonyms
  • STAP-1
  • BRDG1
• Synonyms name
  • BCR downstream signaling 1
• GenBank acession
  • AB023483
• Locus
  4q13.2
• Discovery year
  2007-08-09
• Entrez gene record
  26228
• Pubmed identfication
  • 10518561
  • 10679268
• RefSeq identity
  • NM_012108
• Classification
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000129304

Gene info

• Identity
  HGNC:39073
• Gene
  BCRP1
• Long gene name
  BCR pseudogene 1
• Synonyms gene name
  • breakpoint cluster region pseudogene 1
• Synonyms
  • BCR-1
• Locus
  22q11.23
• Discovery year
  2010-09-30
• Entrez gene record
  644079
• Pubmed identfication
  • 3267213
• RefSeq identity
  • NG_009423
• VEGA ID
  OTTHUMG00000150768

Gene info

• Identity
  HGNC:12641
• Gene
  UXT
• Long gene name
  ubiquitously expressed prefoldin like chaperone
• Synonyms gene name
  • ubiquitously-expressed transcript
  • ubiquitously-expressed, prefoldin-like chaperone
• Synonyms
  • ART-27
  • STAP1
• Synonyms name
  • androgen receptor trapped clone 27
  • SKP2-associated alpha PFD 1
• GenBank acession
  • AF092737
• Locus
  Xp11.23
• Discovery year
  1998-09-03
• Entrez gene record
  8409
• Pubmed identfication
  • 10087202
  • 16221885
• RefSeq identity
  • NM_153477
• Classification
  • Prefoldin subunits
• VEGA ID
  OTTHUMG00000021453

Gene info

• Identity
  HGNC:1015
• Gene
  BCRP2
• Long gene name
  BCR pseudogene 2
• Synonyms gene
  • BCR2
  • BCRL2
• Synonyms gene name
  • breakpoint cluster region-like 2
  • breakpoint cluster region pseudogene 2
• Synonyms
  • BCR-2
• Locus
  22q11.21
• Discovery year
  2001-06-22
• Entrez gene record
  400892
• Pubmed identfication
  • 3267213
• RefSeq identity
  • NG_007131
• VEGA ID
  OTTHUMG00000150627

Gene info

• Identity
  HGNC:1017
• Gene
  BCRP4
• Long gene name
  BCR pseudogene 4
• Synonyms gene
  • BCR4
  • BCRL4
• Synonyms gene name
  • breakpoint cluster region-like 4
  • breakpoint cluster region pseudogene 4
• Synonyms
  • BCR-4
• GenBank acession
  • D87002
• Locus
  22q11.22
• Discovery year
  2001-06-22
• Entrez gene record
  616
• Pubmed identfication
  • 9074928
• RefSeq identity
  • NG_000002
• VEGA ID
  OTTHUMG00000151175

Gene info

• Identity
  HGNC:1014
• Gene
  BCR
• Long gene name
  BCR activator of RhoGEF and GTPase
• Synonyms gene
  • D22S11
  • BCR1
• Synonyms gene name
  • breakpoint cluster region
  • BCR, RhoGEF and GTPase activating protein
• Synonyms
  • D22S662
  • CML
  • PHL
  • ALL
• Locus
  22q11.23
• Discovery year
  1986-01-01
• Entrez gene record
  613
• Pubmed identfication
  • 1657398
  • 18070886
• RefSeq identity
  • NM_004327
• Classification
  • C2 domain containing
  • My-T-BRC complex
  • Dbl family Rho GEFs
  • Pleckstrin homology domain containing
• VEGA ID
  OTTHUMG00000150655
• Locus Specific Databases
  • LRG_1112

MeSH Data

• Name
  Gene Knockdown Techniques
• Concept
  Scope note: The artificial induction of GENE SILENCING by the use of RNA INTERFERENCE to reduce the expression of a specific gene. It includes the use of DOUBLE-STRANDED RNA, such as SMALL INTERFERING RNA and RNA containing HAIRPIN LOOP SEQUENCE, and ANTI-SENSE OLIGONUCLEOTIDES.
• Tree numbers
  • E05.393.335.500
• Qualifiers
  ethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data

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