Sphingosine 1 Phosphate Receptor 1 (EDG-1)

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Description

The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

Gene target

Sphingosine Phosphate Receptor EDG-1
Gene symbol

S1PR1, HEXIM1, S1PR5, LPAR2, LPAR1, BUD31, S1PR3, LPAR3, IGHVII-1-1, MIR1-1
Short name

Sphingosine 1 Phosphate Receptor 1 (EDG-1)
Alternative name

Sphingosine 1 Phosphate Receptor 1 (EDG-1)

Identity

HGNC:3165
Gene

S1PR1
Long gene name

sphingosine-1-phosphate receptor 1
Synonyms gene
- EDG1
Synonyms gene name
- endothelial differentiation, sphingolipid G-protein-coupled receptor, 1
Synonyms
- edg-1
- D1S3362
- CD363
GenBank acession
- M31210
Locus

1p21.2
Discovery year

1998-05-15
Entrez gene record

1901
Pubmed identfication
- 2160972
- 9488656
RefSeq identity
- NM_001400
Classification
- CD molecules
- Sphingosine 1-phosphate receptors
VEGA ID

OTTHUMG00000010835

Identity

HGNC:14299
Gene

S1PR5
Long gene name

sphingosine-1-phosphate receptor 5
Synonyms gene
- EDG8
Synonyms gene name
- endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
Synonyms
- Edg-8
GenBank acession
- AK074661
Locus

19p13.2
Discovery year

2001-01-02
Entrez gene record

53637
Pubmed identfication
- 10799507
RefSeq identity
- NM_030760
Classification
- Sphingosine 1-phosphate receptors
VEGA ID

OTTHUMG00000180581

Identity

HGNC:3168
Gene

LPAR2
Long gene name

lysophosphatidic acid receptor 2
Synonyms gene
- EDG4
Synonyms gene name
- endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4
Synonyms
- EDG-4
- LPA2
GenBank acession
- AF011466
Locus

19p13.11
Discovery year

1999-02-15
Entrez gene record

9170
Pubmed identfication
- 9525886
- 9804623
RefSeq identity
- NM_004720
Classification
- Lysophosphatidic acid receptors
VEGA ID

OTTHUMG00000182328

Identity

HGNC:3166
Gene

LPAR1
Long gene name

lysophosphatidic acid receptor 1
Synonyms gene
- EDG2
Synonyms gene name
- endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2
Synonyms
- edg-2
- rec.1.3
- vzg-1
- Gpcr26
- Mrec1.3
- LPA1
GenBank acession
- U80811
Locus

9q31.3
Discovery year

1998-05-15
Entrez gene record

1902
Pubmed identfication
- 8922387
- 9070858
RefSeq identity
- NM_057159
Classification
- Lysophosphatidic acid receptors
VEGA ID

OTTHUMG00000020486

Identity

HGNC:29629
Gene

BUD31
Long gene name

BUD31 homolog
Synonyms gene
- G10
Synonyms gene name
- G10 maternal transcript homolog (Xenopus laevis)
- BUD31 homolog (yeast)
- BUD31 homolog (S. cerevisiae)
Synonyms
- YCR063W
- EDG-2
- EDG2
- fSAP17
- Cwc14
Synonyms name
- functional spliceosome-associated protein 17
GenBank acession
- BC022821
Locus

7q22.1
Discovery year

2006-03-10
Entrez gene record

8896
Pubmed identfication
- 7841202
RefSeq identity
- NM_003910
Classification
- Spliceosomal C complex
- NTC associated proteins
- Spliceosomal B complex
- Spliceosomal Bact complex
- Spliceosomal P complex
VEGA ID

OTTHUMG00000154602

Identity

HGNC:3167
Gene

S1PR3
Long gene name

sphingosine-1-phosphate receptor 3
Synonyms gene
- EDG3
- C9orf47
- C9orf108
Synonyms gene name
- endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
- chromosome 9 open reading frame 47
- chromosome 9 open reading frame 108
Synonyms
Synonyms name
- sphingosine-1-phosphate receptor 3
GenBank acession
- AF022139
Locus

9q22.1
Discovery year

1998-05-15
Entrez gene record

1903
Pubmed identfication
- 8878560
- 9409733
RefSeq identity
- NM_005226
Classification
- Sphingosine 1-phosphate receptors
VEGA ID

OTTHUMG00000020173

Identity

HGNC:14298
Gene

LPAR3
Long gene name

lysophosphatidic acid receptor 3
Synonyms gene
- EDG7
Synonyms gene name
- endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7
Synonyms
- LP-A3
- Edg-7
- RP4-678I3
- HOFNH30
- LPA3
GenBank acession
- AF127138
Locus

1p22.3
Discovery year

2001-01-02
Entrez gene record

23566
Pubmed identfication
- 10488122
RefSeq identity
- NM_012152
Classification
- Lysophosphatidic acid receptors
VEGA ID

OTTHUMG00000009925

Identity

HGNC:5670
Gene

IGHVII-1-1
Long gene name

immunoglobulin heavy variable (II)-1-1 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable (II)-1-1
- immunoglobulin heavy variable (II)-1-1 pseudogene
Synonyms
- IGHV(II)-1-1
GenBank acession
- AB019441
Locus

14q32.33
Discovery year

2000-04-17
Entrez gene record

28377
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000152325